Tacrolimus in pediatric renal transplantation

Transplantation
R ShapiroT E Starzl

Abstract

Tacrolimus was used as the primary immunosuppressive agent in 69 pediatric renal transplantations between December 17, 1989, and June 30, 1995. Children undergoing concomitant or prior liver and/or intestinal transplantation were excluded from analysis. The mean recipient age was 10.3+/-5.0 years (range, 0.7-17.5 years). Seventeen (24.6%) children were undergoing retransplantation, and six (8.7%) had a panel reactive antibody level of 40% or higher. Thirty-nine (57%) cases were with cadaveric kidneys, and 30 (43%) were with living donors. The mean donor age was 28.0+/-14.7 years (range, 1.0-50.0 years), and the mean cold ischemia time for the cadaveric kidneys was 27.0+/-9.4 hr. The antigen match was 2.7+/-1.2, and the mismatch was 3.1+/-1.2. All patients received tacrolimus and steroids, without antibody induction, and 26% received azathioprine as well. The mean follow-up was 32+/-20 months. One- and 4-year actuarial patient survival rates were 100% and 95%. One- and 4-year actuarial graft survival rates were 99% and 85%. The mean serum creatinine level was 1.2+/-0.8 mg/dl, and the calculated creatinine clearance was 82+/-26 ml/min/1.73 m2. The mean tacrolimus dose was 0.22+/-0.14 mg/ kg/day, and the level was 9.5+/-4.8 ng/ml....Continue Reading

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Citations

Jun 6, 2003·Indian Journal of Pediatrics·Asha Moudgil
May 8, 2000·Indian Journal of Pediatrics·A Moudgil, S C Jordan
Mar 27, 2001·Transplantation Proceedings·S ShishidoH Nakai
Aug 15, 2002·Transplantation Proceedings·F CitterioM Castagneto
Sep 2, 1998·Transplantation Proceedings·R B Ettenger
Sep 2, 1998·Transplantation Proceedings·R N Fine, A Tejani
Sep 29, 1999·Transplantation Proceedings·R Shapiro
Nov 27, 1999·Transplantation Proceedings·M L JordanT E Starzl
Nov 27, 1999·Transplantation Proceedings·J P SquiffletY Vanrenterghem
Aug 26, 1998·The Laryngoscope·B V LattyakA K Lalwani
Feb 12, 1999·Transplantation·R ShapiroT E Starzl
Mar 30, 1999·Transplantation·R ShapiroT E Starzl
Jun 1, 2000·Transplantation·Y NakataK Furusho
Jul 9, 2004·Transplantation·Christoph D DieterleRüdiger Landgraf
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Eba H HathoutLeonard L Bailey
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Quanxing WangXiao-Kang Li
Jan 16, 1999·Pediatric Clinics of North America·B KosmachJ Reyes
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G FillerB Hocher

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