Tacrolimus versus cyclosporine microemulsion for heart transplant recipients: a meta-analysis

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Fan YeR Hetzer

Abstract

Tacrolimus and cyclosporine microemulsion are the 2 major immunosuppressants for heart transplantation. Several studies have compared these 2 drugs, but the outcomes were not consistent. This meta-analysis of randomized controlled trials compared the beneficial and harmful effects of tacrolimus and microemulsion cyclosporine for heart transplant recipients. Electronic databases and manual bibliography searches were conducted. A meta-analysis was performed of all randomized controlled trials comparing tacrolimus with cyclosporine microemulsion as primary immunosuppression for heart transplant recipients. Data for mortality, acute rejection, withdrawals, and adverse events were extracted. The combined results of the data of the randomized controlled trials were summarized as relative risk with 95% confidence intervals. The study assessed 7 randomized controlled trials including 885 patients. There was no difference in mortality at 1 year between recipients treated with tacrolimus and cyclosporine microemulsion. Tacrolimus-treated patients had less acute rejection risk at 6 months and 1 year. Fewer patients stopped tacrolimus than cyclosporine microemulsion. The rate of new-onset diabetes mellitus requiring insulin treatment was h...Continue Reading

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Citations

Jun 23, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle R DenburgMary B Leonard
Jan 26, 2010·Néphrologie & thérapeutique·Nassim KamarLionel Rostaing
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Aug 20, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Rachel J BubikStacy A Bernard

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