Tacrolimus vs. cyclosporine A as primary immunosuppression in pediatric renal transplantation: a NAPRTCS study

Pediatric Transplantation
Alicia NeuB A Fivush

Abstract

Using the North American Renal Transplant Cooperative Study (NAPRTCS) database, we performed a retrospective cohort study of 986 pediatric renal transplant recipients (index transplant 1997-2000) who were treated either with Cyclosporine A (CSA), Mycophenolate Mofetil (MMF) and steroids (n = 766) or tacrolimus (TAC), MMF and steroids (n = 220) to examine potential difference in clinical outcomes between these two groups. In the first year post-transplant, time to first rejection (29.1% vs. 29%, p = 0.840), risk for rejection [Adjusted Relative Risk (aRR) 1.01, 95% Confidence Interval (CI) 0.77, 1.323], graft survival (96.8% vs. 97.9%, p = 0.607) and risk for graft failure (aRR 0.988, 95% CI 0.64, 1.928) were not significantly different in TAC and CSA-treated patients. At 2 yr post-transplant, there was also no difference in risk for rejection (aRR 0.918, 95% CI 0.669, 1.259), graft survival (91.4% vs. 95.1%, p = 0.152) and risk for graft failure (aRR 0.702, 95% CI 0.461, 1.762) in the subset of 391 CSA-treated patients and 77 TAC-treated patients on whom 2 yr follow data were available in the database. TAC-treated patients were significantly less likely to require antihypertensive medication at 1 yr [aRR 0.74 (95% CI 0.454, 0.6...Continue Reading

Citations

Nov 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte Hadtstein, Franz Schaefer
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Maria ShipkovaEberhard Wieland
Nov 29, 2011·Néphrologie & thérapeutique·Patrick Niaudet
Sep 16, 2004·Pediatric Transplantation·Jameela A Kari, Richard S Trompeter
Jul 29, 2005·Pediatric Transplantation·Britta HöckerUNKNOWN Tricontinental MMF Suspension Study Group
Mar 1, 2008·Pediatric Transplantation·Zhi-Xian WuJian-Ming Tan
Jan 9, 2008·Pediatric Transplantation·Guido Filler, Ajay P Sharma
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T S LarsonJ A Velosa
Feb 24, 2007·Nephrology·Steven McTaggart, UNKNOWN Caring for Australians with Renal Impairment (CARI)
Aug 17, 2006·Pediatric Transplantation·D A Kelly
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R GrendaF Janssen
Mar 2, 2013·Pediatric Transplantation·Violette M G J GijsenSaskia N de Wildt
Oct 25, 2008·Journal of Pediatric Urology·Eduardo RuizJorge Ferraris
Jul 26, 2005·Critical Reviews in Oncology/hematology·Anna L TaylorJ Andrew Bradley
Jul 30, 2016·Pediatric Dermatology·Alexander L FogelJoyce M C Teng
Oct 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jorge R FerrarisRafael T Krmar
Feb 27, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnieszka Prytuła, Teun van Gelder
May 10, 2008·Pediatric Transplantation·Robert EttengerUNKNOWN Everolimus Pediatric Study Group
May 12, 2006·Journal of the American Society of Nephrology : JASN·William HarmonMohamed H Sayegh
Aug 22, 2018·Transplantation·Jessica M RuckJacqueline Garonzik-Wang
Jan 19, 2020·Expert Review of Clinical Immunology·Burkhard Tönshoff
Oct 1, 2020·Pediatric Transplantation·Luiza do Nascimento Ghizoni PereiraPaulo Cesar Koch-Nogueira
Jun 18, 2004·Transplantation·Flavio Vincenti
Mar 26, 2004·Transplantation Proceedings·B D Maes, Y F Ch Vanrenterghem
Jul 4, 2021·Pediatric Transplantation·Shanthi S BalaniSarah J Kizilbash

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.