Tactile Angle Discrimination Decreases due to Subjective Cognitive Decline in Alzheimer's Disease.

Current Alzheimer Research
Zhilin ZhangChunlin Li

Abstract

Subjective Cognitive Decline (SCD) is the early preclinical stage of Alzheimer's Disease (AD). Previous study provided an invaluable contribution by showing that a tactile angle discrimination system can be used to distinguish between healthy older individuals and patients with mild cognitive impairment and AD. However, that study paid little attention to the relationship between tactile angle discrimination and SCD. Therefore, a means of differentiating Normal Controls (NCs), elderly subjects with SCD, patients with amnestic Mild Cognitive Impairment (aMCI), and AD is urgently needed. In the present study, we developed a novel tactile discrimination device that uses angle stimulation applied to the index finger pad to identify very small differences in angle discrimination between the NC (n = 30), SCD (n = 30), aMCI (n = 30), and AD (n = 30) groups. Using a three-alternative forced-choice and staircase method, we analyzed the average accuracy and threshold of angle discrimination. We found that accuracy significantly decreased while thresholds of angle discrimination increased in the groups in the following order: NC, SCD, aMCI, and AD. The area under the receiver operating characteristic curve also indicated that the tactile ...Continue Reading

References

Dec 1, 1991·Brain : a Journal of Neurology·A D BaddeleyH Spinnler
Nov 30, 1990·Behavioural Brain Research·P De WeerdG A Orban
Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Jan 1, 1996·Somatosensory & Motor Research·J C Stevens, K K Choo
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·D SuvàJ Miklossy
May 23, 2002·Brain : a Journal of Neurology·Francisco Vega-Bermudez, Kenneth O Johnson
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jan 25, 2007·Physical Therapy·Scott W Shaffer, Anne L Harrison
Jul 16, 2008·Archives of Neurology·Sid E O'BryantJohn A Lucas
Oct 6, 2009·Attention, Perception & Psychophysics·S J Lederman, R L Klatzky
Jun 24, 2011·Trends in Neurosciences·Michael EwersHarald Hampel
Aug 27, 2011·Biochimica Et Biophysica Acta·Yang WangAndrew J Saykin
Sep 20, 2011·Progress in Neurobiology·Bruno VellasHarald Hampel
Jan 10, 2012·Journal of Geriatric Psychiatry and Neurology·Jihui LuJianping Jia
Mar 1, 2012·Current Alzheimer Research·Philipp A ThomannJohannes Schroder
Jun 30, 2012·Current Alzheimer Research·Ahmed AbdulkadirStefan Klöppel
Sep 4, 2012·Neuropsychologia·Rebecca E AmariglioDorene M Rentz
May 1, 2013·Brain Connectivity·Anne HafkemeijerSerge A R B Rombouts
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Aug 19, 2015·Journal of the American Geriatrics Society·Michael RönnlundLars-Göran Nilsson
Feb 8, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rachel F BuckleyUNKNOWN AIBL study
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Svenja BrodtMonika Schönauer
Nov 9, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·José L MolinuevoUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Feb 21, 2018·Brain : a Journal of Neurology·Nicolai FranzmeierMichael Ewers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.