Tactile assessment for the reversibility of rocuronium-induced neuromuscular blockade during propofol or sevoflurane anesthesia.

Anesthesia and Analgesia
Kyo S KimJae M Lee

Abstract

We sought to determine whether tactile train-of-four (TOF) count can predict the efficacy of neostigmine administration for rocuronium-induced blockade during propofol or sevoflurane anesthesia, and to follow subsequent recovery until the TOF ratio reached 0.9. One-hundred-sixty patients, divided into eight equal groups, were randomly allocated to maintenance of anesthesia with propofol or sevoflurane. The tactile response of the adductor pollicis to TOF stimulation was evaluated on one arm, and the mechanomyographic response was recorded on the other. Neuromuscular block was induced with rocuronium 0.6 mg/kg and maintained with rocuronium to 15% of the control first twitch in TOF. Neostigmine 0.07 mg/kg was administered on reappearance of the first (Group I), second (Group II), third (Group III), or fourth (Group IV) tactile TOF response in each anesthesia. At this time, sevoflurane or the propofol dosage was reduced in each group (n = 20 in each group). The times from administration of neostigmine until the TOF ratio recovered to 0.7, 0.8, and 0.9 were recorded. The times [median (range)] to TOF ratio = 0.9 were 8.6 (4.7-18.9), 7.5 (3.4-9.8), 5.4 (1.6-8.6), and 4.7 (1.3-7.2) min in Groups I-IV during propofol anesthesia, resp...Continue Reading

References

Oct 1, 1988·British Journal of Anaesthesia·V Y HaraldstedL Hasselstrøm
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Citations

Sep 4, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·François Donati
May 4, 2011·Revista española de anestesiología y reanimación·F Martínez TorrenteF Gilsanz Rodríguez
Sep 28, 2010·Journal of Clinical Anesthesia·Wolfgang LedererKarin S Khuenl-Brady
Oct 17, 2009·Journal of Clinical Anesthesia·Anthony L Kovac
Jul 26, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·M Beaussier, M A Boughaba
May 14, 2008·Expert Opinion on Pharmacotherapy·François Donati
Nov 14, 2017·Anaesthesia·S J Brull, R C Prielipp
Jan 24, 2006·Anesthesia and Analgesia·Guy CammuThierry Deloof
Sep 25, 2012·Anesthesiology·Stephan R ThilenSanjay M Bhananker
Sep 17, 2016·Anesthesia and Analgesia·Aaron F Kopman, Mohamed Naguib
Jun 13, 2013·Anesthesia and Analgesia·Yoshifumi KotakeJunzo Takeda
Nov 8, 2016·Anesthesiology·Sorin J Brull, Aaron F Kopman
Aug 9, 2016·Anesthesiology·Glenn S Murphy, Aaron F Kopman
May 23, 2013·Anesthesiology·Stephan R ThilenSanjay M Bhananker
Jun 3, 2020·Journal of Intensive Care·J Ross RenewRichard C Prielipp
Jul 11, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Tim KampmeierMartin Westphal
Jan 12, 2020·Anaesthesia Critical Care & Pain Medicine·Benoît PlaudBertrand Debaene
Jan 14, 2020·Anaesthesia Critical Care & Pain Medicine·Sorin J Brull, Lars Eriksson

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