Tactile hyperesthesia, altered epidermal innervation and plantar nerve injury in the hindfeet of rats housed on wire grates

Brain Research
A P MizisinK C Dines

Abstract

The effects of wire grates on nerve injury and recovery were examined in rats housed in cages with sawdust-covered solid flooring. For the first 3 weeks of the study, 20 rats were housed on sawdust alone and 20 rats were housed in cages with wire grates placed over the sawdust. For the remaining 9 weeks, 10 animals housed on sawdust had wire grates added to their cages, while grates were removed from the cages of 10 animals. The effects of tactile stimulation on hindpaw plantar skin was measured weekly using the Von Frey filament test. Intraepidermal innervation using PGP 9.5 immunostaining and plantar nerve histology were assessed at the end of the 12-week study. After just 1 week on grates, hindpaw withdrawal thresholds were already markedly decreased and remained low until the grates were removed at 3 weeks. Thresholds returned to normal by 4 weeks after removal of the grates. Wire grates also induced increases in PGP 9.5 immunoreactive intraepidermal fine nerve endings that were normalized after grate removal. Demyelination, Wallerian degeneration and Renaut bodies were induced in the medial plantar nerve in rats housed in cages with wire-grate flooring. Nerve injury was largely resolved after 9 weeks on sawdust flooring. T...Continue Reading

References

Mar 1, 1975·Journal of the Neurological Sciences·D NearyR W Gilliatt
Mar 1, 1988·Archives of Histology and Cytology·B L Munger, C Ide
Apr 1, 1973·Journal of Neuropathology and Experimental Neurology·A K Asbury
Oct 1, 1967·Journal of Neurology, Neurosurgery, and Psychiatry·P M Fullerton, R W Gilliatt
Dec 1, 1983·Journal of the Neurological Sciences·J A OrtmanJ R Mendell
Jan 1, 1981·Journal of the Neurological Sciences·D JeffersonR A Eames
Aug 7, 1995·The Journal of Comparative Neurology·M L Reynolds, M Fitzgerald
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Nov 15, 1993·The Journal of Comparative Neurology·F L RiceJ Arvidsson

❮ Previous
Next ❯

Citations

Aug 6, 2014·Neurotoxicology and Teratology·Tracey E BeasleyPhilip J Bushnell
Mar 1, 2015·Neurotoxicology and Teratology·Philip J BushnellJohn M Rogers
Oct 3, 1999·The Journal of Investigative Dermatology·S T Hsieh, W M Lin
Apr 4, 2008·Acta histochemica·Kristina K BeiswengerAndrew P Mizisin
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaGuido Cavaletti
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·K VissersT Meert
Mar 1, 2012·Pain·Jordi Casanova-MollaJosep Valls-Solé
Jun 20, 2008·Reviews in the Neurosciences·Aysha Z AkhtarChad B Sandusky
Jun 18, 1999·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S Hill, S Hall
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Feb 22, 2018·Archives of Physiology and Biochemistry·Zafer SahinHaluk Kelestimur
Jun 28, 2012·Journal of the Peripheral Nervous System : JPNS·Jordi Casanova-MollaJosep Valls-Solé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.