Tactile stimulation inhibits locomotion produced by stimulation of the lateral hypothalamus in the anesthetized rat

Physiology & Behavior
E A Gross, H M Sinnamon

Abstract

Rats were anesthetized with Nembutal and suspended in a stereotaxic apparatus so that their limbs contacted the outer surface of a 30-cm diameter wheel. Stimulation in the lateral hypothalamus (0.5 msec cathodal pulses at 50 Hz, up to 150 microA) produced locomotor stepping which turned the wheel. During continuous locomotion maintained by electrical stimulation, tactile stimulation was applied manually for 5-sec periods to various body regions in six subjects. Profound inhibition of locomotor stepping was produced in all subjects by mild pressure applied to the nose or the vibrissae pad. Vibrissae pad stimulation either ipsilateral or contralateral to the stimulation site was effective. Stroking of the vibrissae inhibited locomotion in only 2 of 6 subjects and in these cases the effective stimulation was contralateral to the brain stimulation site. With pressure applied to more caudal body regions, including the dorsum, the abdomen and the tail, the inhibition was less pronounced and less consistent than that produced by pressure on the snout region. The findings indicate that the tactile system provides an important modulation of locomotion and that the anesthetized locomoting rat offers a useful preparation for its further s...Continue Reading

References

Jun 1, 1976·Journal of Comparative and Physiological Psychology·J F MarshallE M Stricker
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P TeitelbaumO S Marin
May 1, 1977·Psychological Bulletin·J W Gustafson, S L Felbain-Keramidas
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D R Levitt, P Teitelbaum
Sep 14, 1984·Science·E LagerweijJ M van Ree
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J T ChengP Teitelbaum
Feb 1, 1980·Journal of Comparative and Physiological Psychology·T SchallertP Teitelbaum
Jan 1, 1981·Behavioral and Neural Biology·D G WebsterM E Meyer
Oct 12, 1984·Science·P W Leslie, J T McCabe

❮ Previous
Next ❯

Citations

Jan 1, 1995·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·A C Chester
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.