Tadalafil - a therapeutic option in the management of BPH-LUTS

International Journal of Clinical Practice
C CarsonD G Wong

Abstract

Men with signs of benign prostatic hyperplasia (BPH) may experience lower urinary tract symptoms (LUTS) such as urinary frequency, urgency, intermittence, nocturia, straining, incomplete emptying or a weak urinary stream. The effective management of LUTS suggestive of BPH (BPH-LUTS) requires careful consideration of several factors, including the severity of a patient's symptoms, concurrent or other coexisting medical conditions, the ability to improve symptoms and impact quality of life (QOL), as well as the potential side effects of available treatment options. Several clinical studies have assessed phosphodiesterase type 5 (PDE5) inhibitors in reducing LUTS; however, tadalafil is the only PDE5 inhibitor approved for the treatment of signs and symptoms of BPH, as well as in men with both erectile dysfunction (ED) and the signs and symptoms of BPH. This review examined articles that assessed tadalafil in patients with signs and symptoms of BPH, with or without erectile dysfunction (ED), which led to regulatory approval in the United States and Europe. In dose-ranging and confirmatory studies, results demonstrate that tadalafil significantly improved total International Prostate Symptom Score (IPSS) following 12 weeks of treatm...Continue Reading

References

Mar 11, 2005·The Journal of Urology·John T WeiSteven J Jacobsen
Nov 18, 2006·International Journal of Clinical Practice·M J NaslundM M Miner
Jul 14, 2007·International Journal of Clinical Practice·M T RosenbergD A Ohl
Jan 27, 2009·Urology·Raymond C RosenUNKNOWN BPH Registry and Patient Survey Steering Committee
Oct 23, 2012·International Journal of Clinical Practice·A D SeftelL Viktrup
Apr 27, 2013·International Journal of Clinical Practice·M KirbyK Wylie

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Citations

Jul 12, 2016·Annals of Medical and Health Sciences Research·A S Elhwuegi
Jul 5, 2016·Expert Opinion on Drug Metabolism & Toxicology·Denise Kreutzwiser, Alice Tseng
May 27, 2017·Oncotarget·Mikhail V Blagosklonny
Sep 20, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyed Mohammad NabaviMohammad Hosein Farzaei
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adam MieczkowskiKrzysztof Woźniak

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