Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion

International Journal of Urology : Official Journal of the Japanese Urological Association
Saori NishijimaHideyuki Yamamoto

Abstract

To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion. A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder. Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucl...Continue Reading

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Citations

Mar 12, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Motoaki Saito
Dec 23, 2021·Annals of Medicine·Kamil BałabuszekRadosław Pietura

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