PMID: 2510753Oct 1, 1989Paper

Taenia crassiceps metacestode vesicular fluid antigens shared with the Taenia solium larval stage and reactive with serum antibodies from patients with neurocysticercosis

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
J KunzE Geyer

Abstract

After removal of host (mouse) serum proteins (albumin, transferrin, IgG and another five unidentified proteins) by immunoaffinity chromatography, the vesicular fluid of T. crassiceps metacestodes (TcVF) was immunoelectrophoretically examined for antigens recognized by rabbit antiserum to aqueous crude extract of T. solium cysticerci. Based on a precipitate pattern developed in electroimmunodiffusion, nine cross-reactive antigens could be demonstrated. In the ELISA, TcVF was shown to be a potent antigen for the demonstration of IgG antibodies in the sera of Mexican patients (n = 14) with confirmed neurocysticercosis (mean E490 values +/- SD: 0.39 +/- 0.38) although it was less sensitive when compared to T. solium VF (0.95 +/- 0.54). Sensitivity was much higher using cross-reactive TcVF antigens selected by immunoaffinity chromatography with rabbit IgG antibodies to larval T. solium crude extract (0.87 +/- 0.57). SDS-PAGE fluorograph of cross-reactive, radioiodinated TcVF protein antigens and selected by antibodies of individual neurocysticercosis sera (n = 13), exhibited six to nine bands depending on the serum tested. Altogether ten 125I-labelled proteins (Mr range from about 20,000 to 200,000) were recognized by neurocysticero...Continue Reading

References

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Citations

Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·H H GarciaUNKNOWN Cysticercosis Working Group in Peru
Aug 17, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·A FleuryE Sciutto
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·E C BuenoP G Leser
Aug 30, 2001·Journal of Clinical Microbiology·A X PardiniJ A Livramento
Feb 13, 2010·Journal of Biomedicine & Biotechnology·Armandina GarzaPrema Robinson
Feb 22, 2012·PLoS Pathogens·Prema RobinsonDavid J Tweardy
Feb 16, 2013·The Journal of Parasitology·Edda SciuttoCarlos Larralde
Sep 28, 2005·Tropical Medicine & International Health : TM & IH·G C ArrudaC L Rossi
Dec 23, 2014·BioMed Research International·Mitra KhumbattaPrema Robinson
Aug 8, 2015·PLoS Neglected Tropical Diseases·Agnès FleuryGladis Fragoso
Jan 1, 1997·Revista Do Instituto De Medicina Tropical De São Paulo·A P FerreiraJ A Livramento
Jul 11, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·N M EspíndolaA J Vaz
Nov 7, 2001·The Journal of Parasitology·G FragosoE Lamoyi
Sep 26, 2006·The Journal of Parasitology·Shripad PatilA Clinton White
Nov 29, 2007·Parasite Immunology·E SciuttoC Larralde
Jul 1, 1997·Infection and Immunity·P RobinsonA C White

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