Taenia solium and Taenia ovis: stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres

Experimental Parasitology
Charles G GauciMarshall W Lightowlers

Abstract

Recombinant antigens that have been cloned from Taenia solium and Taenia ovis have been shown to be highly effective when used as vaccines against cysticercosis in the intermediate hosts. This study investigated the presence of mRNA encoding the TSOL18 and TSOL16 antigens in different life-cycle stages of T. solium, and their related homologues in T. ovis. Reverse transcription-PCR and Southern blotting demonstrated that the antigens are stage-specifically expressed in the oncosphere. The apparent absence of expression of TSOL18 in the metacestode life-cycle stage suggests that the vaccine based on this antigen targets exclusively the early stages in the development of the parasite.

References

Apr 1, 1990·Molecular and Biochemical Parasitology·A CamposJ P Laclette
Aug 1, 1993·Molecular and Biochemical Parasitology·C M da SilvaA Zaha
Jul 1, 1995·Molecular and Biochemical Parasitology·J G WaterkeynA F Cowman
Jul 1, 1995·Molecular and Biochemical Parasitology·C G Gauci, M W Lightowlers
May 1, 1997·Molecular and Biochemical Parasitology·J WaterkeynM Lightowlers
Jul 31, 1999·International Journal for Parasitology·A PlancarteM W Lightowlers
Sep 10, 1999·International Journal for Parasitology·M W Lightowlers
Jul 25, 2003·Veterinary Parasitology·M W LightowlersC Sato
Sep 19, 2003·International Journal for Parasitology·M W LightowlersA J Read
Aug 24, 2004·Infection and Immunity·Ana FlisserMarshall W Lightowlers
Nov 22, 2005·Molecular and Biochemical Parasitology·Charles G GauciMarshall W Lightowlers

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Citations

Jan 25, 2008·Parasitology Research·R Michael E ParkhouseLeslie J S Harrison
Dec 12, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Juntao DingXuepeng Cai
May 18, 2010·International Journal for Parasitology·Marshall W Lightowlers
Sep 14, 2007·Molecular and Biochemical Parasitology·Holger MaytaUNKNOWN Cysticercosis Working Group in Peru
Nov 4, 2009·International Journal for Parasitology·Abdul JabbarMarshall W Lightowlers
Dec 28, 2007·International Journal for Parasitology·Charles GauciMarshall W Lightowlers
Feb 11, 2015·World Neurosurgery·Celene Mulholland, Andrew Little
Feb 9, 2010·International Journal for Parasitology·Emmanuel AssanaMarshall W Lightowlers
Aug 22, 2009·Biology of Reproduction·Marcos R ChiarattiFlávio V Meirelles
Apr 13, 2018·PLoS Neglected Tropical Diseases·Rafaella P M Guimarães-PeixotoAbelardo Silva-Júnior
Sep 1, 2007·Current Opinion in Infectious Diseases·Hector H GarciaPeter M Schantz
Jan 11, 2019·Parasitology Research·Ana Vargas-CallaUNKNOWN Cysticercosis Working Group in Peru

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