Tafenoquine for the prophylaxis, treatment and elimination of malaria: eagerness must meet prudence

Future Microbiology
Fernando ValMarcus Vg Lacerda


Malaria puts more than 3 billion people at risk of infection and causes high morbidity and mortality. Plasmodium vivax forms hypnozoites, which may initiate recurrences, even in the absence of reinfection or superinfection. Until recently, the only drug available for eliminating hypnozoites was primaquine (PQ), which, given its short half-life, requires a relatively long course of treatment. Tafenoquine (TQ) is a PQ analog with a longer half-life. This enables radical cure of malaria with a single dose and overcomes adherence issues associated with PQ, thereby increasing effectiveness in real-life settings. Clinical studies have provided sound evidence for TQ's safety and efficacy against malaria, which recently led to its approval by the US FDA. Here, we review aspects of TQ, including how to avoid hemolytic anemia in G6PD deficient patients. We believe that TQ promises to be a major advance toward malaria elimination.


Jun 1, 1985·British Journal of Clinical Pharmacology·G W MihalyA M Breckenridge
Apr 1, 1984·British Journal of Clinical Pharmacology·G W MihalyA M Breckenridge
Nov 1, 1982·The American Journal of Tropical Medicine and Hygiene·W A KrotoskiP S Stanfill
Dec 1, 1993·Annals of Tropical Medicine and Parasitology·W PetersW K Milhous
May 23, 1998·The American Journal of Tropical Medicine and Hygiene·R P BruecknerB G Schuster
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·J L VennerstromW K Milhous
Aug 13, 1999·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·L ConstantinoJ Iley
Jan 1, 2000·Journal of the Royal Society of Medicine·W Peters
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R NotaroL Luzzatto
Nov 9, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G D ShanksR Brueckner
Dec 12, 2001·British Journal of Clinical Pharmacology·M D EdsteinB G Charles
Oct 5, 2002·The American Journal of Tropical Medicine and Hygiene·Michael RamharterWalther H Wernsdorfer
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Braden R HaleStephen L Hoffman
Mar 11, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter NasveldKarl Rieckmann
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael D EdsteinKarl H Rieckmann
Sep 21, 2004·The Journal of Infectious Diseases·Douglas S WalshThomas G Brewer
Oct 16, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas S WalshSornchai Looareesuwan
Mar 3, 2007·The Journal of Infectious Diseases·Mallika ImwongNicholas J White
May 23, 2007·Antimicrobial Agents and Chemotherapy·Bruce G CharlesMichael D Edstein
Jul 21, 2009·Toxicology and Applied Pharmacology·Shobana GanesanLarry A Walker
Aug 22, 2009·The Lancet Infectious Diseases·Ivo MuellerHernando A del Portillo
Oct 20, 2009·Malaria Journal·Sheila Vitor-SilvaMarcus V G Lacerda
Jun 4, 2010·The American Journal of Tropical Medicine and Hygiene·Koen Peeters GrietensDionicia Gamboa
Jul 29, 2010·Journal of the History of Biology·Miles B Markus
Feb 12, 2011·PLoS Medicine·UNKNOWN malERA Consultative Group on Vaccines
Oct 13, 2011·Malaria Journal·Nicholas J White
Dec 15, 2011·Malaria Journal·Elza A PereiraCor J F Fontes
May 25, 2013·British Journal of Clinical Pharmacology·Ann K MillerAndrew P Beelen
Jun 21, 2013·Malaria Journal·Brandon S PybusVictor Melendez
Jul 3, 2013·The Lancet Infectious Diseases·G Dennis Shanks, Nicholas J White
Oct 26, 2013·Malaria Journal·Mathieu NacherBernard Carme
Nov 16, 2013·Malaria Journal·Rosalind E HowesSimon I Hay

❮ Previous
Next ❯


May 8, 2021·RNA Biology·Diana Renteria AlvarezKausik Chakrabarti
Jun 15, 2021·Malaria Journal·Kelry Mazurega Oliveira DinellyGisely Cardoso Melo

❮ Previous
Next ❯

Methods Mentioned


Clinical Trials Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.