Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

Nature Communications
Jônatas S AbrahãoBernard La Scola

Abstract

Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.

References

Mar 29, 2003·Science·Bernard La ScolaDidier Raoult
Oct 16, 2004·Science·Didier RaoultJean-Michel Claverie
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Karsten SuhreJean-Michel Claverie
Jun 22, 2006·Genome Biology·Jean-Michel Claverie
Mar 4, 2008·Nature Reviews. Microbiology·Didier Raoult, Patrick Forterre
May 1, 2009·PLoS Biology·Chuan XiaoMichael G Rossmann
Dec 10, 2009·Parasitology·J E Smith
Jan 30, 2010·Lancet·Didier Raoult
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias G FischerCurtis A Suttle
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Defne ArslanJean-Michel Claverie
Dec 28, 2011·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Gregory P FournierJ Peter Gogarten
Oct 6, 2012·The ISME Journal·Patrick Forterre
Feb 11, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alexandra Nunes, João P Gomes
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matthieu LegendreJean-Michel Claverie
Jun 27, 2014·Frontiers in Genetics·Medha Raina, Michael Ibba
Aug 27, 2014·Extremophiles : Life Under Extreme Conditions·Dimitry Y SorokinGerard Muyzer
Aug 1, 2013·Biomolecular Concepts·Jonathan N Gonzalez-FloresPaul R Copeland
Apr 17, 2015·Journal of Virology·Dorine Gaëlle RetenoBernard La Scola
Jul 2, 2015·Viruses·Felipe L AssisPhilippe Colson
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Matthieu LegendreJean-Michel Claverie
Aug 20, 2016·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Jan 14, 2017·Science·Vorrapon ChaikeeratisakJoe Pogliano
Feb 17, 2017·PLoS Genetics·Jônatas Santos AbrahãoBernard La Scola

❮ Previous
Next ❯

Citations

May 31, 2018·Development, Growth & Differentiation·Naofumi ItoKunimasa Ohta
Jul 6, 2018·Microbes and Environments·Hiroyuki Ogata
Dec 14, 2018·Journal of Virology·Ana Cláudia Dos Santos Pereira AndradeJônatas Santos Abrahão
Mar 14, 2019·Annals of the New York Academy of Sciences·Luis P Villarreal, Guenther Witzany
Mar 30, 2019·Annals of the New York Academy of Sciences·Hervé Seligmann
Feb 8, 2019·Journal of Virology·Genki YoshikawaMasaharu Takemura
Apr 7, 2019·Journal of Molecular Evolution·Jacques Demongeot, Hervé Seligmann
Apr 25, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Liran Ben YaakovAbraham Minsky
Jul 11, 2019·Virus Genes·Beata Tokarz-DeptułaWiesław Deptuła
Oct 8, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David M NeedhamAlexandra Z Worden
Sep 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Julien GuglielminiMorgan Gaia
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·David M NeedhamAlexandra Z Worden
Oct 28, 2019·Microbes and Environments·Motohiro Akashi, Masaharu Takemura
Oct 16, 2019·History and Philosophy of the Life Sciences·Sávio Torres de FariasFrancisco Prosdocimi
Jan 23, 2020·Nature·Frederik SchulzTanja Woyke
Feb 8, 2020·Genome Biology and Evolution·Rijja Hussain BokhariArshan Nasir
Feb 14, 2020·Archives of Virology·Ludmila Karen Dos Santos SilvaJônatas Santos Abrahão
Apr 7, 2020·Nature Communications·Mohammad MoniruzzamanFrank O Aylward
Apr 30, 2020·Biology·Jacques Demongeot, Alexandra Henrion-Caude
Feb 24, 2019·Viruses·Sergio Morgado, Ana Carolina Vicente
Jun 20, 2019·Nucleic Acids Research·Alexandra ZinovievChristopher U T Hellen
May 31, 2019·Nature Reviews. Microbiology·Mart KrupovicEugene V Koonin
Nov 7, 2019·Virology Journal·Graziele OliveiraJônatas Abrahão
Feb 2, 2020·Virology Journal·Gabriel Augusto Pires de SouzaJônatas Santos Abrahão
Apr 10, 2020·Frontiers in Microbiology·Eric R GannSteven W Wilhelm
May 28, 2020·Viruses·Khalil Geballa-KoukoulasGuillaume Blanc
Apr 20, 2019·Frontiers in Microbiology·Lorena C F SilvaJônatas S Abrahão
Jan 19, 2019·Scientific Reports·Graziele OliveiraJônatas Santos Abrahão
Feb 3, 2019·Biochemical Society Transactions·Kevin KrammDina Grohmann
May 6, 2019·Viruses·Nadav Brandes, Michal Linial
Aug 11, 2019·Viruses·Said MougariBernard La Scola
Jun 11, 2019·Frontiers in Microbiology·Said MougariBernard La Scola
Feb 2, 2020·Scientific Reports·Nisrine ChelkhaPhilippe Colson
May 12, 2020·Frontiers in Microbiology·Rodrigo Araújo Lima RodriguesJônatas Santos Abrahão
Oct 7, 2018·Archives of Virology·Rodrigo Araújo Lima RodriguesJônatas Santos Abrahão
Dec 14, 2018·F1000Research·Eugene V Koonin, Natalya Yutin

❮ Previous
Next ❯

Datasets Mentioned

BETA
KY523104
MF405918
PXD007583

Methods Mentioned

BETA
transmission electron microscopy
Transmission
aminoacylation
electron microscopy
scanning electron microscopy
electrophoresis
PCR
transfection
fluorescence microscopy

Software Mentioned

ARAGORN
GeneMarkS
SPADES
Blast2GO
IMOD
ABYSS
CGUA ( General Codon Usage Analysis
Blastp
CGUA ( General Codon Usage Analysis )
blastn

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms