Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults

The Cochrane Database of Systematic Reviews
Helen L PetskyA B Chang

Abstract

The measurement of severity and control of asthma in both children and adults can be based on subjective or objective measures. It has been advocated that fractional exhaled nitric oxide (FeNO) can be used to monitor airway inflammation as it correlates with some markers of asthma. Interventions for asthma therapies have been traditionally based on symptoms and/or spirometry. To evaluate the efficacy of tailoring asthma interventions based on exhaled nitric oxide in comparison to clinical symptoms (with or without spirometry/peak flow) for asthma related outcomes in children and adults. We searched the Cochrane Airways Group Specialised Register of Trials, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and reference lists of articles. The last search was completed in December 2006. All randomised controlled comparisons of adjustment of asthma therapy based on exhaled nitric oxide compared to traditional methods (primarily clinical symptoms and spirometry/peak flow). Results of searches were reviewed against pre-determined criteria for inclusion. Relevant studies were independently selected in duplicate. Two authors independently assessed trial quality and extracted data. Authors were contacted for...Continue Reading

Citations

Jan 1, 2011·Allergy & Rhinology·John B HaganRavinder J Singh
Nov 3, 2009·Annals of Thoracic Medicine·Abdullah A Abba
Jul 17, 2010·The European Respiratory Journal·T M BastainF D Gilliland
Mar 11, 2010·Therapeutic Advances in Respiratory Disease·Carolyn Kercsmar
Sep 19, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alessandra SandriniDeborah H Yates
Oct 22, 2008·American Journal of Respiratory and Critical Care Medicine·Erik J SaudeDarryl J Adamko
May 19, 2009·American Journal of Respiratory Cell and Molecular Biology·Lester Kobzik
Mar 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G Gibson

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