PMID: 11899107Mar 20, 2002Paper

Tailoring bioanalysis for PK studies supporting drug discovery

Current Topics in Medicinal Chemistry
P M TimmermanB A Ingelse

Abstract

Over the last years, there has been an exponentially growing need and interest to bring pharmacokinetic expertise into discovery. In order to allow a multidisciplinary selection and a higher attrition rate, both the in vivo and in vitro pharmacokinetic parameters of an ever increasing number of tentative new chemical entities are evaluated in an earlier phase of Drug Discovery. A higher attrition rate at the beginning of the pipeline should result in a lower attrition rate at a later stage in development. In this process, the bioanalytical laboratory has become increasingly important. Analytical strategies needed to be adapted to cope with novel experimental designs such as cassette dosing, cassette analysis or 96-well techniques. At the same time, HT-synthesis programs surfaced a broader variety of chemical classes to be investigated, disfavoring further generalization of analytical approaches. Progress in lab automation, improved chromatographic techniques and the proliferation of LC-MS/MS enabled the analyst to deal with these challenges much faster and with a higher level of confidence. Quality standards regarding method development and method validation, setting the boundaries for more than a decade, needed to be titrated ...Continue Reading

Citations

Dec 4, 2004·Analytical and Bioanalytical Chemistry·Harald John
Oct 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Larry M MallisOliver J McConnell
Oct 17, 2007·Biomedical Chromatography : BMC·Nuggehally R Srinivas
Nov 24, 2004·Neuropharmacology·Hilde LavreysenAnne S J Lesage
Jul 29, 2004·Drug Discovery Today·Prasarn Manitpisitkul, Ronald E White
Sep 4, 2015·Biomarkers in Medicine·Nuggehally R Srinivas, Ramesh Mullangi
May 1, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M P McIntoshR A Rajewski
Mar 15, 2006·BioTechniques·Pengfei SongCharles R Yates

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