Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

International Journal of Pharmaceutics
Nicole B BissetYao-Da Dong

Abstract

Lipid-based liquid crystalline materials are being developed as drug delivery systems. However, the use of these materials for delivery of large macromolecules is currently hindered by the small size of the water channels in these structures limiting control over diffusion behaviour. The addition of the hydration-modulating agent, sucrose stearate, to phytantriol cubic phase under excess water conditions incrementally increased the size of these water channels. Inclusion of oleic acid enabled further control of swelling and de-swelling of the matrix via a pH triggerable system where at low pH the hexagonal phase is present and at higher pH the cubic phase is present. Fine control over the release of various sized model macromolecules is demonstrated, indicating future application to controlled loading and release of large macromolecules such as antibodies.

References

Sep 28, 1990·Science·R Langer
Jul 5, 2003·International Journal of Pharmaceutics·Ben J Boyd
Jul 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·J Clogston, M Caffrey
Nov 9, 2006·Physical Chemistry Chemical Physics : PCCP·Thomas Kaasgaard, Calum J Drummond
Sep 23, 2008·Advances in Colloid and Interface Science·Anan Yaghmur, Otto Glatter
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wye-Khay FongBen J Boyd
Apr 7, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Jun 29, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Stefan SalentinigOtto Glatter
Apr 2, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Renata Negrini, Raffaele Mezzenga
Oct 4, 2011·International Journal of Pharmaceutics·Stephanie PhanBen J Boyd
Nov 3, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Renata Negrini, Raffaele Mezzenga
Dec 15, 2012·Journal of Colloid and Interface Science·Xavier MuletCalum J Drummond
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandru Zabara, Raffaele Mezzenga

❮ Previous
Next ❯

Citations

Aug 24, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Elżbieta JabłonowskaRenata Bilewicz
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
Mar 18, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Reza GhanbariRaffaele Mezzenga
Oct 7, 2016·Physical Chemistry Chemical Physics : PCCP·Debby P ChangTommy Nylander
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Mar 10, 2019·The Journal of Chemical Physics·Reza GhanbariRaffaele Mezzenga
Jun 25, 2020·Pharmaceutics·Lisa Rahnfeld, Paola Luciani
Dec 28, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chelsea R ThornNicky Thomas
Apr 29, 2021·ACS Infectious Diseases·Chelsea R ThornNicky Thomas
Apr 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Reza GhanbariRaffaele Mezzenga
Nov 29, 2017·Bioconjugate Chemistry·Nicolas AlcarazBen J Boyd
Nov 3, 2021·ACS Applied Materials & Interfaces·Brendan P DyettCharlotte E Conn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.