Take the 'A' train: on fast tracks to the cell surface.

Cellular and Molecular Life Sciences : CMLS
M MarieJaakko Saraste

Abstract

Cholesterol, certain lipids, membrane-bound and soluble proteins, as well as viruses that are synthesized in the endoplasmic reticulum (ER), reach the plasma membrane (PM) via non-classical pathway(s) that remain poorly understood. Typical for this transport is (i) its insensitivity to brefeldin A (BFA), which dissociates selected coat complexes from membranes, resulting in the disassembly of the Golgi apparatus; (ii) its rapid kinetics as compared to the classical secretory pathway; and (iii) its role in the trafficking of lipid raft components. Based on results showing that the intermediate compartment (IC) at the ER-Golgi boundary constitutes a stable tubular network that maintains its dynamics in the presence of BFA, we propose that two bidirectional Golgi-bypass pathways to the PM exist, a direct route from early IC elements, and another, reminiscent of the yeast secretory pathway, from late IC elements via the endosomal system. These pathways have implications for the organization of the secretory processes in different cell types.

Citations

Apr 25, 2012·Cell and Tissue Research·Kristian PrydzJaakko Saraste
Dec 7, 2013·PloS One·Blaine BiselFrancesco Saverio Pavone
Nov 16, 2010·The Journal of Biological Chemistry·Estelle RousseletNabil G Seidah
Dec 27, 2012·Molecular Immunology·Sharon CohenNurit Hollander
May 4, 2010·Journal of Insect Physiology·Dolphine A AmenyaOsvaldo Marinotti
Sep 28, 2012·Thrombosis and Haemostasis·Hariharan SubramanianChristine Mannhalter
Apr 12, 2016·Brain Research·Sonam Parakh, Julie D Atkin
Mar 20, 2013·Journal of Biomechanics·Z AbusaraW Herzog
May 6, 2016·Frontiers in Cell and Developmental Biology·Jaakko Saraste
Nov 26, 2015·F1000Research·Sara BitamAleksander Edelman
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Emily H Stoops, Michael J Caplan
Apr 7, 2011·The Journal of Pharmacology and Experimental Therapeutics·Kazuho SakamotoJunko Kimura
Jun 20, 2020·Cell Structure and Function·Yuto MatsuiNobuko Hosokawa
Sep 3, 2018·Histochemistry and Cell Biology·Jaakko Saraste, Michaël Marie
Sep 10, 2019·Frontiers in Cell and Developmental Biology·Jaakko Saraste, Kristian Prydz
Apr 14, 2020·Cellular Signalling·Valeria PadovanoMichael J Caplan
Dec 27, 2015·Biochimica Et Biophysica Acta·Chiara Zurzolo, Kai Simons
May 4, 2010·Trends in Cell Biology·Yuru DengSepp D Kohlwein

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