Taking Aim at Glycolysis with CDK8 Inhibitors

Trends in Endocrinology and Metabolism : TEM
Robert P Fisher

Abstract

Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

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Citations

Nov 10, 2018·Transcription·Matthew D GalbraithJoaquín M Espinosa
Apr 6, 2019·Current Medicinal Chemistry·Xiao LvZhouling Xie
Dec 2, 2020·European Journal of Medicinal Chemistry·Dan WuXinhua Liu

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