Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults

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Simone KühnJürgen Gallinat

Abstract

While previous attempts to train self-control in humans have frequently failed, we set out to train response inhibition using computer-game elements. We trained older adults with a newly developed game-based inhibition training on a tablet for two months and compared them to an active and passive control group. Behavioural effects reflected in shorter stop signal response times that were observed only in the inhibition-training group. This was accompanied by structural growth in cortical thickness of right inferior frontal gyrus (rIFG) triangularis, a brain region that has been associated with response inhibition. The structural plasticity effect was positively associated with time spent on the training-task and predicted the final percentage of successful inhibition trials in the stop task. The data provide evidence for successful trainability of inhibition when game-based training is employed. The results extend our knowledge on game-based cognitive training effects in older age and may foster treatment research in psychiatric diseases related to impulse control.

References

Nov 6, 2012·Brain Structure & Function·Simone KühnJürgen Gallinat

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Citations

Jul 11, 2018·PloS One·Barbara C N MüllerSimone Kühn
Mar 21, 2019·Journal of Behavioral Medicine·Evan M FormanKatrijn Houben
Jun 24, 2020·Journal of Cognitive Neuroscience·Nahian S ChowdhuryJustin A Harris
Sep 19, 2020·Translational Behavioral Medicine·Evan M FormanAdrienne S Juarascio
Sep 16, 2020·Cerebral Cortex·Hugo NajbergLucas Spierer
Jul 14, 2021·Neuroscience and Biobehavioral Reviews·Sakshi DhirRebecca A Segrave

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