Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Koldo BerganzoJuan J Zarranz


Tako-tsubo-like cardiomyopathy (TTC) is much more common than originally thought. The exact pathophysiology of TTC is unclear. The most accepted theory proposes myocardial stunning of neurogenic origin, supported by the frequent antecedent of emotional or physical stress, suggesting a catecholamine-mediated mechanism. We present a patient with this syndrome and bilateral damage of the dorsal medulla oblongata likely affecting both solitary tract nuclei. Our case points to a link between baroreflex failure and TTC, highlighting the important role of sympathetic discharge in the pathophysiology of TTC.


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