Talaromyolides A-D and Talaromytin: Polycyclic Meroterpenoids from the Fungus Talaromyces sp. CX11

Organic Letters
Xun CaoBin Wu

Abstract

Talaromyolides A-D (1-4) and talaromytin (5) were isolated from a marine fungus Talaromyces sp. CX11. Their structures were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, X-ray crystallography experiments, and time-dependent density functional theory electronic circular dichroism calculations. Talaromyolides A and D represent two novel carbon skeletons. Talaromytin exhibits two slowly interconverting conformers in DMSO-d6 and CH3OH-d4 that were studied by temperature-dependent NMR experiments. Talaromyolide D exhibits potent antiviral activity against pseudorabies virus (PRV) with a CC50 value of 3.35 μM.

References

Jul 29, 2009·Natural Product Reports·Regina Geris, Thomas J Simpson
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Jun 28, 2015·Bioorganic & Medicinal Chemistry Letters·Hiroyuki YamazakiMichio Namikoshi
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Citations

Sep 21, 2019·Natural Product Reports·Robert A Hill, Andrew Sutherland

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