TALE nucleases: tailored genome engineering made easy

Current Opinion in Biotechnology
Claudio Mussolino, Toni Cathomen

Abstract

Custom-made designer nucleases have evolved into an indispensable platform to precisely alter complex genomes for basic research, biotechnology, synthetic biology, or human gene therapy. In this review we describe how transcription activator-like effector nucleases (TALENs) have rapidly developed into a chief technology for targeted genome editing in different model organisms as well as human stem cells. We summarize the technological background and provide an overview of the current state-of-the-art of TALENs with regard to activity and specificity of these nucleases for targeted genome engineering.

References

Jun 16, 1989·Science·M R Capecchi
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·P RouetM Jasin
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J BitinaiteI Schildkraut
Dec 13, 2000·Molecular and Cellular Biology·M BibikovaS Chandrasegaran
May 6, 2003·Science·Marina BibikovaDana Carroll
Jul 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Stephen AlwinToni Cathomen
Dec 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michal MinczukAaron Klug
Jul 3, 2007·Nature Biotechnology·Jeffrey C MillerEdward J Rebar
Nov 21, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tatjana I CornuToni Cathomen
May 1, 2008·Nature Methods·Cherie L RamirezJ Keith Joung
May 27, 2008·Nature Biotechnology·Xiangdong MengScot A Wolfe
Jun 12, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Toni Cathomen, J Keith Joung
Nov 6, 2008·PloS One·Carola EnglerSylvestre Marillonnet
Nov 13, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Eva-Maria HändelToni Cathomen
Apr 30, 2009·Annual Review of Phytopathology·Jens Boch, Ulla Bonas
Jul 25, 2009·Science·Aron M GeurtsRoland Buelow
Oct 20, 2009·Biochemical and Biophysical Research Communications·Tomoaki MoriTakashi Sera
Nov 26, 2009·Science·Matthew J Moscou, Adam J Bogdanove
Jun 24, 2010·Current Opinion in Plant Biology·Adam J BogdanoveThomas Lahaye
Jul 28, 2010·Genetics·Michelle ChristianDaniel F Voytas
Aug 19, 2010·Nucleic Acids Research·Cem SöllüToni Cathomen
Aug 19, 2010·Nature Reviews. Genetics·Fyodor D UrnovPhilip D Gregory
Nov 5, 2010·Protein Engineering, Design & Selection : PEDS·S ArnouldJ Smith
Nov 26, 2010·Journal of Molecular Biology·Sivaprakash RamalingamSrinivasan Chandrasegaran
Dec 24, 2010·Nature Biotechnology·Jeffrey C MillerEdward J Rebar
Dec 25, 2010·Current Gene Therapy·Dana Carroll
Jan 11, 2011·Current Opinion in Microbiology·Heidi Scholze, Jens Boch
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Magdy M MahfouzJian-Kang Zhu
Jan 27, 2011·EMBO Molecular Medicine·Claudio MussolinoEnrico Maria Surace
Mar 23, 2011·Nucleic Acids Research·Robert MorbitzerThomas Lahaye
May 3, 2011·Biochemistry·Yuka ShimizuDavid J Segal

❮ Previous
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Citations

Oct 1, 2013·Molecular Genetics and Genomics : MGG·Feng WangQingyou Xia
Oct 1, 2013·Cell and Tissue Research·Jan M Deussing
Sep 22, 2012·Current Diabetes Reports·Fiona McMurrayRoger D Cox
Apr 3, 2013·Trends in Biotechnology·Coral González-PrietoMatxalen Llosa
Jun 12, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Engin GürlevikFlorian Kühnel
Aug 2, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Axel Schambach, Thomas Moritz
Sep 10, 2013·Nature Biotechnology·Eric M MendenhallBradley E Bernstein
Feb 12, 2013·Nature Methods·Morgan L MaederJ Keith Joung
Feb 28, 2013·Nature Methods·Annekatrin Richter, Jens Boch
Mar 30, 2013·Nature Methods·David Jonah Grunwald
Nov 28, 2012·Database : the Journal of Biological Databases and Curation·Victor Zeng, Cassandra G Extavour
Aug 7, 2012·Human Molecular Genetics·Jessica E Young, Lawrence S B Goldstein
Jan 1, 2013·Nucleic Acids Research·Diana SchenkweinSeppo Ylä-Herttuala
Sep 25, 2012·Nucleic Acids Research·Marloes L de GrooteMarianne G Rots
Sep 29, 2012·Nucleic Acids Research·Andrew C MercerCarlos F Barbas
Sep 27, 2012·Genome Research·Christine MerlinSteven M Reppert
Apr 10, 2013·Genome Research·Marion PiganeauErika Brunet
May 21, 2013·Annual Review of Neuroscience·Z Josh Huang, Hongkui Zeng
May 28, 2013·Journal of Diabetes Research·Gabriela da Silva XavierGuy A Rutter
Apr 5, 2013·PloS One·Azadeh AryanZach N Adelman
Nov 10, 2013·Future Microbiology·Musa MarimaniPatrick Arbuthnot
Feb 21, 2014·International Journal of Molecular Sciences·Nobutaka Nakashima, Kentaro Miyazaki
May 28, 2014·Glycobiology·Catharina SteentoftHenrik Clausen
Jul 24, 2013·Nucleic Acids Research·Tomonori KatsuyamaRenato Paro
Sep 2, 2014·Nature Reviews. Cancer·Daniel W Stuckey, Khalid Shah
May 6, 2014·Nucleic Acids Research·Claudio MussolinoToni Cathomen
Dec 7, 2013·Expert Opinion on Biological Therapy·Susan JarminGeorge Dickson
Feb 26, 2016·Neuropharmacology·Sourav R ChoudhuryPaola Grandi
Jun 26, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Kunling Chen, Caixia Gao
Jan 29, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Pavel SimaraDan S Kaufman
Aug 18, 2012·International Journal of Medical Microbiology : IJMM·Christian KlotzFrank Seeber
Sep 8, 2015·Current Opinion in Pharmacology·Claudio MussolinoToni Cathomen
Feb 26, 2013·The Journal of Pathology·Louise van der Weyden, David J Adams
Feb 8, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tetsushi SakumaTakashi Yamamoto
Jul 11, 2012·Biotechnology Journal·Ning SunHuimin Zhao
Nov 21, 2013·Biotechnology and Bioengineering·Ning SunHuimin Zhao
Jan 7, 2014·Development, Growth & Differentiation·Tetsushi Sakuma, Knut Woltjen

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