Abstract
Cdk5 kinase, a cyclin-dependent kinase family member, is a key regulator of cytoskeletal remodeling in the brain. Cdk5 is essential for brain development during embryogenesis. After birth, it is essential for numerous neuronal processes such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity is deregulated in various brain disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and ischemic stroke, resulting in profound remodeling of the neuronal cytoskeleton, loss of synapses, and ultimately neurodegeneration. This review focuses on the "good and bad" Cdk5 in the brain and its pleiotropic contribution in regulating neuronal actin cytoskeletal remodeling. A vast majority of physiological and pathological Cdk5 substrates are associated with the actin cytoskeleton. Thus, our special emphasis is on the numerous Cdk5 substrates identified in the past two decades such as ephexin1, p27, Mst3, CaMKv, kalirin-7, RasGRF2, Pak1, WAVE1, neurabin-1, TrkB, 5-HT6R, talin, drebrin, synapsin I, synapsin III, CRMP1, GKAP, SPAR, PSD-95, and LRRK2. These substrates have unraveled the molecul...Continue Reading
References
Apr 7, 1995·Cell·C D Nobes, A Hall
Nov 10, 1995·The Journal of Biological Chemistry·D TangJ H Wang
Sep 29, 1994·Nature·L H TsaiE Harlow
Apr 1, 1996·Genes & Development·M NikolicL H Tsai
Mar 28, 1998·The Journal of Biological Chemistry·R ShuangE L Stuenkel
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H T KaoP Greengard
Sep 23, 1998·Nature·M NikolicL H Tsai
Mar 26, 1999·Science·L C SandersP de Lanerolle
Nov 13, 1999·Nature Cell Biology·D C EdwardsG N Gill
Feb 29, 2000·The Journal of Biological Chemistry·P PenzesB A Eipper
Jun 1, 2000·Nature·M S LeeL H Tsai
Jul 15, 2000·Neuron·L R ZukerbergL H Tsai
Sep 28, 2000·Cerebral Cortex·A TashiroR Yuste
Oct 31, 2000·The Journal of Comparative Neurology·L A Ligon, O Steward
Dec 16, 2000·The Journal of Comparative Neurology·X M MaB A Eipper
Aug 15, 2001·Neuron·D T PakM Sheng
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·R Dhavan, L H Tsai
Oct 10, 2002·Neuron·Yukio SasakiYoshio Goshima
Nov 2, 2002·The Journal of Comparative Neurology·Vincent A PieriboneHung-Teh Kao
Jan 22, 2003·Neuroscience·S D NorrholmP Greengard
Jan 20, 2004·Journal of Medical Genetics·M VenturinP Riva
Apr 14, 2004·Genes & Development·Arnaud BessonJames M Roberts
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sashi KesavapanyHarish C Pant
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Satoru TakahashiAshok B Kulkarni
May 11, 2005·Journal of Neurobiology·Sarah E NeweyLinda Van Aelst
Aug 25, 2005·Nature Methods·Yoshiko SugiyamaShigeo Okabe
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·F RoselliO F X Almeida
Dec 13, 2005·Nature Cell Biology·Takeshi KawauchiMikio Hoshino
Jul 25, 2006·Nature·Yong KimPaul Greengard
Dec 5, 2006·Nature Neuroscience·Wing-Yu FuNancy Y Ip
Jan 25, 2007·Annual Review of Biochemistry·Morgan Sheng, Casper C Hoogenraad
Feb 7, 2007·Annual Review of Neuroscience·Veronica A Alvarez, Bernardo L Sabatini
Mar 3, 2007·Neuron·Cecile BatsDaniel Choquet
Mar 8, 2007·PLoS Biology·Zelda H CheungNancy Y Ip
May 29, 2007·Nature Neuroscience·Ammar H HawasliJames A Bibb
Aug 19, 2007·Molecular Biology of the Cell·Frédéric CauseretMargareta Nikolic
Feb 21, 2008·Annual Review of Neuroscience·Jennifer N Bourne, Kristen M Harris
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jee Young SungYong Kim
Apr 22, 2008·Nature Reviews. Neuroscience·Lorenzo A Cingolani, Yukiko Goda
May 16, 2008·Molecular Biology of the Cell·Kai-Hui SunKavita Shah
May 24, 2008·Neuron·Daniel P SeeburgMorgan Sheng
Jul 4, 2008·Trends in Neurosciences·Peter Penzes, Kelly A Jones
Jul 17, 2008·Journal of Cell Science·Xiaonan XinBetty A Eipper
Aug 12, 2008·Journal of Neurochemistry·Kai-Hui SunKavita Shah
Aug 23, 2008·Nature Reviews. Molecular Cell Biology·Sarah J Heasman, Anne J Ridley
Oct 4, 2008·Current Opinion in Neurobiology·Marianne RennerAntoine Triller
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Douglas A MeyerJames A Bibb
Apr 14, 2009·Nature Cell Biology·Cai HuangMark H Ginsberg
Jun 16, 2009·Current Opinion in Neurobiology·Yoshihiro YoshiharaDominique Muller
Jul 23, 2009·Synapse·Zhi-Qin XiGuang-Wei Liu
Citations
Jul 29, 2017·Journal of Cell Science·Kumar Nikhil, Kavita Shah
Jan 14, 2018·Brain Pathology·Francesca LonghenaArianna Bellucci
Aug 10, 2019·International Journal of Molecular Sciences·Muhammet OnerHo Lin
Mar 12, 2020·The Analyst·Son T LeArvind Balijepalli
Jul 17, 2019·Experimental Neurobiology·Junghyung ParkYoungjeon Lee
Sep 25, 2019·Scientific Reports·Chia-Yi SuHong-Chen Chen
Apr 14, 2018·Scientific Reports·Evgenia LampropoulouEvangelia Papadimitriou
Aug 28, 2018·Molecular Autism·Jesse BarnesHerbert M Lachman
Mar 16, 2019·Neurochemical Research·Ming-Xing LiXin-Ming Ma
Apr 16, 2020·Journal of Neuroscience Research·Ermei LuKecheng Zhou
Aug 15, 2019·Brain Pathology·Julie C LauterbornChristine M Gall
Aug 8, 2020·International Journal of Molecular Sciences·Keiko UnnoYoriyuki Nakamura
Jan 29, 2019·Frontiers in Neuroscience·Zeba MueedNitesh Kumar Poddar
Jun 2, 2020·Cellular and Molecular Life Sciences : CMLS·Quentin MarlierBrigitte Malgrange
Aug 5, 2020·Journal of Translational Medicine·Zijian LiYanxia Guo
Mar 12, 2019·Journal of Alzheimer's Disease : JAD·Nicole CortésRicardo B Maccioni
Jan 27, 2019·Cells·Kwanhyeong KimDaeho Park
Jun 28, 2018·Molecular Neurobiology·Kumar NikhilKavita Shah
Aug 11, 2020·Pain·Kimberly GomezRajesh Khanna
Jul 2, 2019·Biochemical and Biophysical Research Communications·Jianhong WuHu Zhou
Nov 20, 2018·Neuropharmacology·Rebeca LapresaAngeles Almeida
Aug 6, 2019·Pathology, Research and Practice·Yu LiangDong-Qiu Dai
Dec 4, 2020·International Journal of Molecular Sciences·Rossella Di GiaimoMarianna Crispino
Sep 16, 2018·Biochemical and Biophysical Research Communications·Brett Lee RoachDeepali Bhandari
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ratchaneekorn ReudhabibadhPilaiwanwadee Hutamekalin
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Ming-Shu XuChun-Lei Shan
May 6, 2021·The European Journal of Neuroscience·Lara CostaLucia Ciranna
Aug 19, 2021·Neuroscience and Biobehavioral Reviews·Francesca LonghenaArianna Bellucci
Aug 28, 2021·Drug Design, Development and Therapy·Shuangqiu WangMinghua Wu
Sep 20, 2021·Experimental Neurology·Guillermo FernándezMaría Gabriela Paglini
Jun 12, 2020·Current Neuropharmacology·Kim San Tang