Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jane E KlannJohn T Chang

Abstract

Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function. In this study, we describe a role for talin in maintaining the homeostasis and survival of the regulatory T (Treg) cell pool. T cell-specific deletion of talin in Tln1fl/flCd4Cre mice resulted in spontaneous lymphocyte activation, primarily due to numerical and functional deficiencies of Treg cells in the periphery. Peripheral talin-deficient Treg cells were unable to maintain high expression of IL-2Rα, resulting in impaired IL-2 signaling and ultimately leading to increased apoptosis through downregulation of prosurvival proteins Bcl-2 and Mcl-1. The requirement for talin in maintaining high IL-2Rα expression by Treg cells was due, in part, to integrin LFA-1-mediated interactions between Treg cells and dendritic cells. Collectively, our data suggest a critical role for talin in Treg cell-mediated maintenance of immune homeostasis.

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Citations

Mar 28, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Terhi SavinkoSusanna C Fagerholm
Apr 27, 2018·PLoS Computational Biology·Vasyl V MykuliakVesa P Hytönen
Apr 29, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane E KlannJohn T Chang
Feb 7, 2018·Frontiers in Immunology·Katarzyna I JankowskaJanis K Burkhardt
Sep 27, 2019·Frontiers in Immunology·Tanja JakošJanko Kos
May 19, 2018·Frontiers in Immunology·Brandon L Walling, Minsoo Kim
Nov 5, 2019·Frontiers in Immunology·Silvia DusiBarbara Rossi
Oct 27, 2020·The Journal of Experimental Medicine·Hao SunMark H Ginsberg
Dec 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Ziwei OuKathy K Griendling
Jan 8, 2021·Journal of the American Heart Association·Joshua A UhlornHeddwen L Brooks
Feb 13, 2021·Cancers·Pinelopi A NikolopoulouVassiliki Kostourou

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