PMID: 8943172Jan 1, 1997Paper

Tall-cell variant of papillary thyroid cancer: disregarded entity?

World Journal of Surgery
A RüterS Lennquist

Abstract

The tall-cell variant of papillary thyroid carcinoma (TCV) has been described as an aggressive tumor with a significantly higher incidence of recurrence and mortality than other forms of papillary carcinoma. In some series it has accounted for up to 10%, whereas in other series it has not been reported at all, indicating that there are difficulties identifying it. In a series of 162 consecutively treated patients with papillary thyroid carcinoma treated by total thyroidectomy according to a highly standardized procedure, all specimens were specifically examined by an international group of pathologists to establish the occurrence of TCV. All patients with TCV were studied with regard to local aggressiveness, the presence of metastases, iodine uptake, DNA pattern, thyroglobulin production, treatment (surgical and adjuvant), and outcome (follow-up 3-17 years, median 10 years). At primary histopathologic evaluation by the local pathologist, three patients were recorded as having TCV. At special evaluation by the expert group, eight more cases were found, giving a total of 11 patients in this series (7%). Five of them had extracapsular growth, and four were multifocal. Three had metastases at the time of admission. Seven tumors wer...Continue Reading

Citations

Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Ronald A GhosseinR Michael Tuttle
Oct 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Ronald Ghossein, Virginia A Livolsi
Feb 16, 2010·Thyroid : Official Journal of the American Thyroid Association·Luc G T MorrisIan Ganly
Nov 5, 2010·Journal of Thyroid Research·Scharukh JalisiMichael Lavalley
Nov 14, 2006·Human Pathology·Jean Jacques MichelsStephane Bardet
May 10, 2006·Histopathology·T J Stephenson
Oct 17, 2014·Thyroid : Official Journal of the American Thyroid Association·Tomas A AxelssonJon G Jonasson
Mar 30, 2004·Journal of Surgical Oncology·Mark SywakTravis Ogilvie
Jul 17, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sebastian StenmanJohanna Arola
Nov 21, 2007·The Laryngoscope·Alex Kwok-Cheung LeungStephen C K Law
Jun 3, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yoon Jung ChoiYoung Lyun Oh
Jan 1, 2021·Journal of Clinical Medicine·Alessandro LongheuPietro Giorgio Calò

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