PMID: 8611384Mar 1, 1996Paper

Tallimustine in advanced previously untreated colorectal cancer, a phase II study

British Journal of Cancer
C J PuntI Corradino

Abstract

Tallimustine is a novel benzoyl mustard derivative from distamycin A with a unique mode of action. It is a DNA minor groove binder and produces highly sequence-specific alkylations. Previous studies have shown significant anti-tumour effects in animal models. We performed a phase II study in previously untreated patients with advanced colorectal cancer, using a schedule of i.v. bolus infusions of 900 microgram m-2 once every 4 weeks. Seventeen patients were enrolled, and no responses were documented in 14 evaluable patients. Toxicity mainly consisted a highly selective neutropenia, which warrants further investigation of this agent in combination with myeloid growth factors.

Citations

Aug 14, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·D A Anthoney, C J Twelves
Dec 8, 2009·Journal of Liposome Research·Rita CortesiElisabetta Esposito
Sep 25, 1997·International Journal of Cancer. Journal International Du Cancer·J P ZouM Kafka
Jan 5, 2002·Expert Opinion on Investigational Drugs·S MarchiniM D'Incalci
Aug 7, 2001·The Journal of Biological Chemistry·J M WoynarowskiC J Benham
Dec 2, 1999·Pharmacology & Therapeutics·B S ReddyJ W Lown
Jun 27, 2002·Biochimica Et Biophysica Acta·Jan M Woynarowski

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