PMID: 591443Oct 1, 1977

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties

The Journal of Antibiotics
H KawaguchiK Saito

Abstract

The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a copper-chelated form and showed physico-chemical properties similar to those of the bleomycin-group of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.

Citations

Jan 1, 1981·Cancer Chemotherapy and Pharmacology·C K Mirabelli, S T Crooke
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·J E SchurigW T Bradner
May 15, 1979·FEBS Letters·G R Buettner, L W Oberley

Related Concepts

Actinomycetaceae
Antibiotics, Cytotoxic
Antibiotics, Antifungal
Bacterial Infections
Coliphages
Fermentation
Lethal Dose 50
Leukemia, Experimental
Physicochemical Phenomena

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.