PMID: 6168630Jun 1, 1981Paper

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. IV. New biosynthetic derivatives of tallysomycin

The Journal of Antibiotics
T MiyakiH Kawaguchi

Abstract

A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the Beta-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.

Citations

Jan 1, 1986·Cancer Chemotherapy and Pharmacology·R C GaverR D Smyth
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·J E SchurigW T Bradner

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