Tamarixetin Exhibits Anti-inflammatory Activity and Prevents Bacterial Sepsis by Increasing IL-10 Production

Journal of Natural Products
Hee Jo ParkYeong-Min Park

Abstract

Sepsis is a systemic inflammatory response to pathogenic infection that currently has no specific pharmaceutical interventions. Instead, antibiotics administration is considered the best available option, despite increasing drug resistance. Alternative strategies are therefore urgently required to prevent sepsis and strengthen the host immune system. One such option is tamarixetin (4'- O-methylquercetin), a naturally occurring flavonoid derivative of quercetin that protects against inflammation. The purpose of this study was to determine whether the anti-inflammatory effects of tamarixetin protect against the specific inflammatory conditions induced in lipopolysaccharide (LPS) or Escherichia coli K1 models of sepsis. Our study showed that tamarixetin reduced the secretion of various inflammatory cytokines by dendritic cells after activation with LPS. It also promoted the secretion of the anti-inflammatory cytokine interleukin (IL)-10 and specifically increased the population of IL-10-secreting immune cells in LPS-activated splenocytes. Tamarixetin showed general anti-inflammatory effects in mouse models of bacterial sepsis and decreased bacteria abundance and endotoxin levels. We therefore conclude that tamarixetin has superior...Continue Reading

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Citations

May 21, 2020·Biotechnology and Applied Biochemistry·Sumangala DarsandhariJae Kyung Sohng
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Darija Šarić MustapićMirza Bojić
Oct 5, 2019·International Journal of Molecular Sciences·Mihee JangYangmee Kim
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anil Kumar ChauhanYangmee Kim
May 22, 2019·Journal of Molecular Histology·Cheng FanHaipeng Guo
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jiayuan ShenJun He
May 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Arash KarimiHelda Tutunchi

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