Tamibarotene inhibit the accumulation of fibrocyte and alleviate renal fibrosis by IL-17A.

Renal Failure
Lixi LiGang Xu

Abstract

Renal fibrosis is a common pathological process in the progression of chronic kidney disease. Accumulating evidence suggests that interleukin-17A (IL-17A) and fibrocytes play crucial roles in the pathogenesis of fibrosis. However, the role of IL-17A in the regulation of renal fibrocytes in renal fibrosis has rarely been reported. Here, we report that the plasma IL-17A level is increased in immunoglobulin A nephropathy (IgAN) patients and is correlated with clinical parameters. Using a mouse model of unilateral ureteral obstruction (UUO), we found that both IL-17A expression and fibrocyte infiltration were increased in the kidneys of UUO mice. Besides, IL-17A enhanced fibrosis and fibrocyte-associated chemokine and activator expression in vitro. Furthermore, inhibition of IL-17A using Am80 (Tamibarotene) decreased fibrocytes and fibrocyte-associated chemokine and activator expression and significantly attenuated renal fibrosis in the UUO mice. Our findings suggest that Am80, which inhibits the accumulation of fibrocytes and alleviates renal fibrosis mediated by IL-17A, maybe a novel therapeutic drug for renal fibrosis.

References

Oct 11, 2007·Drugs of Today·Ishido Miwako, Hiroyuki Kagechika
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Shigeo HisamoriYoshiharu Sakai
Apr 25, 2009·The American Journal of Pathology·Christian KlemannTakashi Yamamura
Jan 27, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Fu-Jun LinXiang-Ru Wu
Aug 7, 2012·Biological & Pharmaceutical Bulletin·Hiroshi FukasawaKoichi Shudo
Feb 13, 2013·Inflammation·Hisako HayashiYusei Ohshima
Jan 1, 2014·Journal of Molecular and Cellular Cardiology·Sarah M WilliamsTimothy A McKinsey
Mar 26, 2014·The Journal of Experimental Medicine·Henrike FleigeReinhold Förster
Jul 16, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel-Constantin ManolescuJolanta Gutkowska
May 12, 2016·Annual Review of Immunology·Alexandre Larange, Hilde Cheroutre
Oct 26, 2016·Differentiation; Research in Biological Diversity·Yu Bo Yang SunJinhua Li
Nov 27, 2016·Lancet·Angela C WebsterPhilip Masson
Jul 27, 2017·Biochemical and Biophysical Research Communications·Ah Young LeemMoo Suk Park
Jul 17, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ran LuoGang Xu
Nov 9, 2018·Frontiers in Immunology·Yanyan LiuGang Xu
Oct 28, 2019·Frontiers in Pharmacology·Vinicius Andrade-OliveiraNiels Olsen Saraiva Câmara

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
PCR
ELISA
flow cytometry

Software Mentioned

Flowjo
GraphPad Prism
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Experimental Medicine
Mark S WilsonThomas A Wynn
Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Katsuya GunjigakeSachio Fushida
The Journal of Immunology : Official Journal of the American Association of Immunologists
Su MiZhuo-Wei Hu
© 2021 Meta ULC. All rights reserved