Taming psoriatic keratinocytes--PTHs' uses go up another notch

Journal of Cellular Biochemistry
J F Whitfield

Abstract

The native parathyroid hormone (PTH) and several of its N-terminal adenylyl cyclase-activating fragments and their analogs have become the star stimulators of bone growth for treating osteoporosis, accelerating fracture healing, and strengthening the anchorage of prosthetic bone implants and one of them (Lilly's Forteo--recombinant hPTH-(1-34) has recently arrived in the clinic. But something entirely different has been lurking in the background-the ability of the adenylyl cyclase stimulating hPTH-(1-34) to calm hyperproliferating keratinocytes and reduce psoriatic lesions. By contrast PTH-(7-34) which cannot stimulate adenylyl cyclase actually stimulates keratinocyte proliferation. Normal keratinocytes make PTHrP after they lift off the basal lamina and have stopped cycling. But they have an unconventional PTH/PTHrP receptor which is not coupled to adenylyl cyclase. Psoriatic keratinocytes do not make PTHrP and have only a broken-down, proliferation-limiting terminal differentiation-driving Notch-Notch ligand mechanism. Putting these and other facts together produces a possible picture of an exogenously applied adenylyl cyclase-activating PTH pinch hitting for the missing PTHrP and restoring normal keratinocyte proliferative a...Continue Reading

References

Jan 1, 1992·Endocrinology·H JouishommeR H Rixon
Jan 1, 1991·Archives of Dermatology·G K Menon, P M Elias
Jul 1, 1995·The Journal of Investigative Dermatology·N M HanafinM F Holick
Jan 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J A DanksT J Martin
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·M F HolickK S Persons
Jun 1, 1997·The Journal of Investigative Dermatology·M B SchilliM F Holick
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J F WhitfieldF R Bringhurst
Oct 4, 2000·Experimental Dermatology·B J NickoloffM F Holick
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·R John MacLeodEdward M Brown
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Apr 11, 2003·Lancet·Mark Lebwohl
Oct 24, 2003·Nature·L M CalviD T Scadden
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jiang Zhu, Stephen G Emerson
Jul 23, 2005·Current Osteoporosis Reports·James F Whitfield

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Citations

Apr 19, 2005·Expert Opinion on Investigational Drugs·James F Whitfield
Aug 10, 2005·Journal of Cellular Biochemistry·James F Whitfield
Sep 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Dimitrios AgasMaria Giovanna Sabbieti
Apr 9, 2020·Frontiers in Immunology·Timothy M SmithRebecca K Martin

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