Taming the Triskelion: Bacterial Manipulation of Clathrin

Microbiology and Molecular Biology Reviews : MMBR
Eleanor A Latomanski, Hayley J Newton

Abstract

The entry of pathogens into nonphagocytic host cells has received much attention in the past three decades, revealing a vast array of strategies employed by bacteria and viruses. A method of internalization that has been extensively studied in the context of viral infections is the use of the clathrin-mediated pathway. More recently, a role for clathrin in the entry of some intracellular bacterial pathogens was discovered. Classically, clathrin-mediated endocytosis was thought to accommodate internalization only of particles smaller than 150 nm; however, this was challenged upon the discovery that Listeria monocytogenes requires clathrin to enter eukaryotic cells. Now, with discoveries that clathrin is required during other stages of some bacterial infections, another paradigm shift is occurring. There is a more diverse impact of clathrin during infection than previously thought. Much of the recent data describing clathrin utilization in processes such as bacterial attachment, cell-to-cell spread and intracellular growth may be due to newly discovered divergent roles of clathrin in the cell. Not only does clathrin act to facilitate endocytosis from the plasma membrane, but it also participates in budding from endosomes and the ...Continue Reading

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Citations

Mar 19, 2020·Cellular Microbiology·Jesús Osuna-PérezEsteban Veiga
Jul 28, 2020·Frontiers in Cellular and Infection Microbiology·Juliana PortesWanderley de Souza
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Maria DudãuMihail E Hinescu
May 9, 2021·Applied Microbiology and Biotechnology·Tomás G VillaAngeles Sánchez-Pérez
Jul 6, 2021·Frontiers in Plant Science·Eytham SouibguiNathalie Poussereau

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