Tamm-Horsfall autoantibodies in interstitial cystitis

The Journal of Urology
D E NealM B Kaack


Interstitial cystitis presents a diagnostic and therapeutic challenge. Although many etiologies, including autoimmunity, have been proposed its pathogenesis remains obscure. Tamm-Horsfall protein has been identified in the superficial urothelium of patients with interstitial cystitis demonstrating abnormal urothelial permeability. Eight patients with a clinical diagnosis of interstitial cystitis underwent cystoscopy and bladder biopsy. Characteristic cystoscopic findings were present, and each patient had chronic inflammation and mast cells by histopathological analysis. Preoperative anti-Tamm-Horsfall protein serum antibody (IgG) titers were determined by enzyme-linked immunosorbent assay (range 500 to 8,000, mean 2,750). A control group of 8 patients with a negative urological history also had titers of 0 to 500 (p = 0.02). The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis. Measurement of serum Tamm-Horsfall protein antibody may prove to be useful as a noninvasive diagnostic test in patients with this disease.


Oct 1, 1978·Urology·Edward M Messing, T A Stamey
Apr 18, 1979·Biochimica Et Biophysica Acta·W van DijkW Ferwerda
Jan 1, 1977·The Journal of Urology·D L Lamm, R F Gittes
Dec 1, 1988·The Journal of Urology·J E FowlerA Mounzer
Jul 1, 1988·Urology·O J ClemmensenH Colstrup
Jan 1, 1987·Scandinavian Journal of Urology and Nephrology·T Sandberg, A Fasth
Jan 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C K Abrass, C W Laird
Feb 1, 1973·The Journal of Urology·H L GordonJ J Yium
Jul 1, 1973·Urology·E J McGuireJ L Cornog
Feb 1, 1974·The Journal of Urology·D C Utz, H Zincke
Nov 1, 1970·The Journal of Urology·K A Hanash, T L Pool
Jan 1, 1970·Scandinavian Journal of Urology and Nephrology·K J OravistoE J Jokinen
Mar 1, 1970·The Journal of Urology·M R Silk
Nov 1, 1970·The Biochemical Journal·A P FletcherW A Ratcliffe


Jun 1, 2000·International Journal of Urology : Official Journal of the Japanese Urological Association·A AkiyamaC Lowell Parsons
Nov 15, 2014·Glycoconjugate Journal·Iwona Kątnik-PrastowskaAgata Matejuk
Nov 1, 1992·The Journal of Urology·A R StoneJ P MacDermott
Jan 1, 1995·The Journal of Urology·D E Bejany, V A Politano
Apr 9, 2005·European Journal of Clinical Investigation·Marcus SäemannGerhard Zlabinger
Oct 12, 2007·Journal of Leukocyte Biology·Katharina PfistershammerPeter Steinberger
Apr 5, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiyuki AkiyamaYukio Homma

Related Concepts

UMOD protein, human
Urinary Bladder
Chronic Disease
Cystoscopic Surgical Procedures
Enzyme-Linked Immunosorbent Assay
Tamm-Horsfall protein

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.