Tamoxifen: a personal retrospective

The Lancet Oncology
V C Jordan

Abstract

Tamoxifen, originally described as an anti-oestrogen and antifertility agent in the rat, is now a pioneering medicine for the treatment and prevention of breast cancer. Its success is the result of an effective collaboration between laboratory research and clinical trial processes. However, this drug is more than just an anti-oestrogen to treat breast cancer. Laboratory and clinical research defined the concept of selective oestrogen receptor modulation in the 1980s. Non-steroidal anti-oestrogens show oestrogen-like activity in bones and lower cholesterol, but block oestrogen action in the breast and uterus. This realisation led to the development of chemical cousins, known as selective oestrogen receptor modulators. One of these compounds, raloxifene, is used for the prevention of osteoporosis, but is currently being tested as a preventive for breast cancer.

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Citations

May 20, 2004·Molecular and Cellular Endocrinology·Yatrik M ShahBrian G Rowan
Jul 27, 2001·Postgraduate Medical Journal·R A SharmaW P Steward
Dec 19, 2015·The Lancet Oncology·Lee S Schwartzberg
Jun 28, 2015·Molecular Oncology·George NotasElias Castanas
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May 20, 2011·Orvosi hetilap·Zsolt NagyJózsef Gábor Joó
Jan 8, 2015·Frontiers in Genetics·Luis Sanchez-Pulido, Chris P Ponting

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