Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats

Journal of Neurotrauma
Jennifer M ColónJorge D Miranda

Abstract

Spinal cord injury (SCI) is a condition with no available cure. The initial physical impact triggers a cascade of molecular and cellular events that generate a nonpermissive environment for cell survival and axonal regeneration. Spinal cord injured patients often arrive at the clinic hours after the initial insult. This indicates the need to study and develop treatments with a long therapeutic window of action and multiactive properties, which target the complex set of events that arise after the initial trauma. We provide evidence that tamoxifen (TAM), a drug approved by the Food and Drug Administration, exerts neuroprotective effects in an animal model when applied up-to 24 h after SCI. We hypothesized that continuous TAM administration will improve functional locomotor recovery by favoring myelin preservation and reducing secondary damage after SCI. Adult female Sprague-Dawley rats (∼230 g) received a moderate contusion to the thoracic (T9-T10) spinal cord, using the MASCIS impactor device. To determine the therapeutic window available for TAM treatment, rats were implanted with TAM pellets (15 mg) immediately or 24 h after SCI. Locomotor function (Basso, Beattie, Bresnahan open field test, grid walk, and beam crossing tests...Continue Reading

References

May 11, 1993·The American Journal of Physiology·J R YankaskasR C Boucher
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Oct 23, 2002·Biology of Reproduction·Krishnan M Dhandapani, Darrell W Brann
Nov 22, 2002·Advances in Physiology Education·Claire E Hulsebosch
Apr 5, 2003·Journal of Neurotrauma·Stephen W ScheffJames E Lumpp
Jul 12, 2003·Journal of Neurosurgery·Harold K KimelbergPaul J Feustel
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill R FaulknerMichael V Sofroniew
Aug 2, 2005·Experimental Neurology·Yonghua ZhangHarold K Kimelberg
Apr 25, 2006·Journal of Neurotrauma·Lisa McKerracher, Haruhisa Higuchi
Apr 25, 2006·Journal of Neurotrauma·Darryl C Baptiste, Michael G Fehlings
Sep 20, 2006·Journal of Neuroscience Research·Johnny D FigueroaJorge D Miranda
May 19, 2009·Psychoneuroendocrinology·Lydia L DonCarlosLuis M Garcia-Segura
Sep 29, 2009·Trends in Neurosciences·Michael V Sofroniew
Jul 6, 2010·Journal of Neurotrauma·John B G RamseyAndrei V Krassioukov
Jul 16, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ozgür IsmailoğluNecdet Demir
Oct 5, 2010·Cell Stem Cell·Fanie Barnabé-HeiderJonas Frisén
Oct 16, 2010·Developmental Neurobiology·Odrick R RosasJorge D Miranda
May 14, 2011·Journal of Neuroendocrinology·M A ArevaloL M Garcia-Segura
May 25, 2011·Pharmacology & Therapeutics·Alexander G RabchevskyJoe E Springer
Mar 5, 2013·World Neurosurgery·Mohamad BydonAli Bydon
May 29, 2013·Pharmacology & Therapeutics·Geniey YangAlexandros G Georgakilas
Jul 28, 2013·Brain Research Bulletin·N E Franco RodríguezS H Dueñas Jiménez
Aug 3, 2013·Journal of Microscopy·J Mutterer, E Zinck
Sep 6, 2013·Journal of Neurotrauma·Jutatip GuptarakOlivera Nesic
Dec 24, 2013·Neuroscience Letters·Mark A AndersonMichael V Sofroniew
May 31, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hong-Yu Wei, Xiao Ma
Jul 19, 2014·Journal of Neurotrauma·Andrew D SauerbeckDana M McTigue
Apr 17, 2015·Neural Regeneration Research·Iris K SalgadoJorge D Miranda

❮ Previous
Next ❯

Citations

Sep 22, 2016·Neural Regeneration Research·Jennifer M Colón, Jorge D Miranda
Mar 27, 2012·Archives of Physical Medicine and Rehabilitation·Martina R SpiessCarolynn Patten
Mar 5, 2019·Journal of Zhejiang University. Science. B·An-Kai XuHui-Min Tao
May 26, 2017·Frontiers in Molecular Neuroscience·Hamideh ShahheydariJulie D Atkin
Dec 23, 2020·Neurotoxicology·Vanessa NaffaaAnne-Laure Schang
Apr 1, 2021·The International Journal of Neuroscience·Jaspreet Kaur, Aditya Mojumdar
Aug 28, 2021·International Journal of Molecular Sciences·Kirsten HülskötterWolfgang Baumgärtner

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
Fluorescence
protein assay
electrophoresis

Software Mentioned

Image Studio Lite
MASCIS
Motic
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.