PMID: 9641459Jun 26, 1998Paper

Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: a prospective paired cohort study

Annals of Surgical Oncology
G H HoE H Ng

Abstract

Recent data suggest that tamoxifen may act by altering serum levels of insulin-like growth factors (IGFs) and their binding proteins (BPs). This prospective paired cohort study evaluated the influence of tamoxifen on serum levels of IGFs and BPs in postmenopausal patients with breast cancer. Blood was collected from 32 postmenopausal patients with breast cancer before and during tamoxifen therapy for at least 6 months. All patients had undergone primary surgery. Serum concentrations of IGF-I, IGF-II, BP-1, and BP-3 were determined by immunoradiometric assays, and Western ligand blots provided a semiquantitative measurement of BP-2, BP-3, and BP-4. Statistical analysis was performed by paired Student's t-test. Mean serum IGF-1 level was significantly lower after tamoxifen treatment (pretreatment: 116.2 ng/mL+/-13.6 [SEM] vs. posttreatment: 77.5 ng/mL+/-7.8; P=.003). In contrast, mean IGF-II levels increased from 651.5+/-62.2 ng/mL to 812.5+/-35.1 ng/mL during treatment (P=.006). Posttreatment levels of BP-1 (92.9 ng/mL+/-7.5) were significantly higher compared to the pretreatment values (28.1 ng/mL+/-4.7; P <.001). Serum concentration of BP-3 also was elevated (pretreatment: 2228.1 ng/mL+/-145.2 vs. posttreatment: 3539.1 ng/mL+/...Continue Reading

References

Mar 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V C Jordan, S Koerner
Nov 1, 1977·The Journal of Endocrinology·V C JordanG Prestwich
Mar 1, 1992·British Journal of Cancer·V M Macaulay
Jan 1, 1992·Breast Cancer Research and Treatment·R F Krywicki, D Yee
Jan 1, 1992·Breast Cancer Research and Treatment·J P Peyrat, J Bonneterre
Nov 7, 1990·Journal of the National Cancer Institute·M PollakR Margolese
Jan 1, 1986·Advances in Clinical Chemistry·R C Baxter
Dec 1, 1986·The Journal of Clinical Investigation·R C Baxter, J L Martin
Feb 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A M SuikkariM Seppälä
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M Binoux, P Hossenlopp
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·W H BusbyD R Clemmons
Nov 1, 1989·The Journal of Clinical Investigation·C L ArteagaC K Osborne
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R G ElginD R Clemmons
Jul 15, 1988·Biochemical and Biophysical Research Communications·M N PollakM Richard
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·B Dawson-HughesS Reichlin
Mar 1, 1984·Clinics in Endocrinology and Metabolism·D R Clemmons, J J Van Wyk
Jan 14, 1994·Biochemical and Biophysical Research Communications·S E Pratt, M N Pollak
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FriedlM Pollak
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T FornanderB von Schoultz

❮ Previous
Next ❯

Citations

Aug 2, 2002·Breast Cancer Research and Treatment·Pamela J GoodwinNicky Hood
Mar 16, 2006·Breast Cancer Research and Treatment·Lorraine L LipscombeJanet E Hux
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Nov 19, 2013·Pituitary·Irida Balili, Ariel Barkan
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rowan T ChlebowskiAnne McTiernan
Nov 13, 2002·European Journal of Clinical Nutrition·L S AugustinC La Vecchia
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Neill PataniMitch Dowsett
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B A Stoll
Feb 25, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DowsettM Baum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.