Tamoxifen and cataracts: a null association

Breast Cancer Research and Treatment
Brian D BradburySusan S Jick

Abstract

Previous studies have reported an increased risk of cataract for breast cancer patients treated with tamoxifen. We assessed whether breast cancer patients treated with tamoxifen were at increased risk of developing cataracts compared to women not prescribed tamoxifen. We used a nested, matched case-control study design and data collected in the General Practice Research Database. We identified all women 30-79 years old who were diagnosed with breast cancer and treated with tamoxifen within 6 months, or with bladder cancer, colorectal cancer or non-melanoma skin cancer between January 1991 and December 1999. From this population, we identified all newly diagnosed cases of cataract. We matched four female controls to each case on age (+/- 1 year), index date and study entry date (+/- 6 months). We assessed the risk of cataracts for current, past and ever users of tamoxifen and according to cumulative use of tamoxifen. We calculated adjusted odds ratios (AOR) and 95% confidence intervals (CI) controlling the matching factors and adjusting for important cataract risk factors. Current tamoxifen users were at no increased risk of cataract (AOR = 1.0, 95% CI: 0.7, 1.4). There was no evidence of an increased risk with increasing cumula...Continue Reading

References

Feb 22, 1992·BMJ : British Medical Journal·C R BentleyW A Aclimandos
Dec 1, 1989·European Journal of Cancer & Clinical Oncology·S LongstaffP Preece
Apr 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherS Legault-Poisson
Aug 15, 1987·American Journal of Ophthalmology·M F Griffiths
Jan 1, 1988·Cancer·A R AshfordT J Garrett
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Jan 1, 1983·Ophthalmology·F T Fraunfelder, S M Meyer
Feb 1, 1983·Acta Ophthalmologica·T Vinding, N V Nielsen
Oct 1, 1994·The Journal of Clinical Investigation·J J ZhangC F Higgins
Oct 1, 1994·The American Journal of Physiology·J J Zhang, T J Jacob
Aug 1, 1995·British Journal of Pharmacology·J J ZhangM A Valverde
Feb 15, 1996·The Journal of Clinical Investigation·J J Zhang, T J Jacob
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G Nayfield, M B Gorin
Apr 29, 1998·American Journal of Ophthalmology·M B GorinD Kaufmann
Jun 27, 1998·British Journal of Clinical Pharmacology·L A García Rodríguez, S Pérez Gutthann
May 16, 2000·The Journal of Allergy and Clinical Immunology·L Derby, W C Maier
Jun 9, 2000·Breast Cancer Research and Treatment·A Paganini-Hill, L J Clark
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Craig C EarleJane C Weeks
May 14, 2003·Pharmacotherapy·Susan S JickHershel Jick
Jun 18, 2003·CA: a Cancer Journal for Clinicians·Herman Kattlove, Rodger J Winn

❮ Previous
Next ❯

Citations

Aug 9, 2011·Current Eye Research·Alvin Eisner, Shiuh-Wen Luoh
Nov 27, 2014·Pharmacoepidemiology and Drug Safety·Elizabeth M KangAdel Abou-Ali
Jan 14, 2009·Radiation Research·Joseph R DynlachtRobert M Bigsby
Feb 7, 2006·Biochimica Et Biophysica Acta·Livia Puljak, Gordan Kilic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.