Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice

Pharmacology, Biochemistry, and Behavior
Duo ChenYong-Meng Xu

Abstract

The present study examines the effects of tamoxifen (TAM) or toremifene (TOR), two triphenylethylene antiestrogen agents, on spatial information in mice by using Morris water maze. In a 30-s free swim trial, the TAM- or TOR-treated mice (intraperitoneally, 30 min before test) spent shorter time than the blank control mice in target quadrant. Compared to saline control group, animals exposed to TAM (1-10 mg/kg i.p., once a day for 5 days) or TOR (3-30 mg/kg i.p., once a day for 5 days) did not show significant difference on the acquisition of place task in Morris water maze. These results suggest that TAM, at the doses of 1-10 mg/kg, and TOR, at the doses of 3-30 mg/kg, impair the retrieval, but not the acquisition, of spatial information task in Morris water maze. It seems, however, that TOR is more potent than TAM on impairing memory retrieval.

References

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·J D Brioni, M P Arolfo
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C D Toran-AllerandN J MacLusky
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·B F PetrieG B Glavin
Dec 21, 1988·Journal of the National Cancer Institute·C A O'BrianB W Anderson
Sep 16, 1985·Biochemical and Biophysical Research Communications·E A Kroeger, L J Brandes
Jan 13, 1984·Biochemical and Biophysical Research Communications·H Y Lam
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
May 1, 1984·Journal of Neuroscience Methods·R Morris
Oct 1, 1994·The Journal of Clinical Investigation·J J ZhangC F Higgins
Jun 1, 1994·Biochemical Pharmacology·C D van den KoedijkJ H Thijssen
Apr 1, 1996·Nature Medicine·D J Grainger, J C Metcalfe
May 2, 1997·Science·I Wickelgren
May 1, 1997·Pharmacology, Biochemistry, and Behavior·D A JettT R Guilarte
Aug 1, 1997·Drugs & Aging·L S Schneider, C E Finch
Oct 1, 1998·European Journal of Pharmacology·M C AllenS P Hardy
Jan 1, 1999·Lancet·W C McCormick, I B Abrass
Jul 17, 1999·Drugs & Aging·B Haynes, M Dowsett

❮ Previous
Next ❯

Citations

Apr 17, 2008·Neuropsychology Review·Jeffrey S WefelChristina A Meyers
Jul 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul NewhouseJulie Dumas
Dec 23, 2008·Physiology & Behavior·Agnès LacreuseJames G Herndon
Mar 11, 2008·Experimental Neurology·M A VogtP Gass
Jan 22, 2011·Psycho-oncology·Florence JolyBénédicte Giffard
Jul 18, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yue HouTao Guo
May 7, 2016·Andrology·E WibowoR J Wassersug
Feb 17, 2017·Frontiers in Neuroscience·Peter RotheneichnerSébastien Couillard-Després
Oct 28, 2019·Genes, Brain, and Behavior·Xin LiTian-Ming Gao
Nov 30, 2019·Frontiers in Behavioral Neuroscience·Anousheh Bakhti-SurooshWendy J Lynch
Jul 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Chia-Ming LeeQuan Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.