Tamoxifen decreases fibroblast function and downregulates TGF(beta2) in dupuytren's affected palmar fascia

The Journal of Surgical Research
M Ann KuhnM C Robson

Abstract

Dupuytren's contracture is a fibroproliferative disorder that is associated with increased collagen deposition. Isoforms of transforming growth factor beta (TGF(beta)), normally TGF(beta1) and TGF(beta2), are involved in the progressive fibrosis of Dupuytren's disease. It has been suggested that downregulation of TGF(beta) may be useful in the treatment of the condition. Tamoxifen, a synthetic nonsteroidal antiestrogen, is known to modulate the production of TGF(beta). This study examined the role of tamoxifen in decreasing fibroblast function and downregulating TGF(beta2). Primary cultures of fibroblasts were obtained from Dupuytren's affected fascia and carpal tunnel affected fascia as a control. Collagen lattices were prepared and populated with the fibroblasts. The fibroblast-populated collagen lattices (FPCL) were then measured for contraction every 24 h for 5 days. Supernatant was obtained from the culture medium following completion of the FPCL portion of the experiment and used for a TGF(beta2) immunoassay. Dupuytren's affected fibroblasts contracted the FPCLs significantly more than carpal tunnel control fibroblasts. Treating the fibroblasts with tamoxifen caused a decreased contraction rate in both Dupuytren's affecte...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M D BrooksM Baum
Mar 1, 1992·The Journal of Hand Surgery·M A BadalamenteS P Sampson
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
Nov 7, 1990·Journal of the National Cancer Institute·M PollakR Margolese
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J S Vande BergP Sicurello
Dec 15, 1983·Cancer·B KinzbrunnerC J Rosenthal
May 1, 1995·Cell Biology International·D A Cox
Jan 1, 1995·The Journal of Hand Surgery·P KloenH J Mankin
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Jan 1, 1994·Breast Cancer Research and Treatment·L C Murphy
Jul 1, 1994·British Journal of Plastic Surgery·M J Timmons
Jan 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T A Dickens, A A Colletta
Mar 1, 1996·The Journal of Hand Surgery·M A BadalamenteK Miyasaka
May 1, 1996·Annals of Plastic Surgery·S YounaiT L Tuan
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·S O'Kane, M W Ferguson
May 26, 1998·Annals of Plastic Surgery·D ChauM T Longaker
Dec 16, 1998·British Journal of Plastic Surgery·D HuG W Cherry
Mar 26, 1999·The Journal of Surgical Research·P SmithM C Robson
Aug 24, 1999·Annals of Plastic Surgery·T Y LeeM T Longaker

❮ Previous
Next ❯

Citations

Jul 29, 2009·Archives of Dermatological Research·Alfredo GragnaniLydia Masako Ferreira
Jan 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A LintermansP Neven
Jun 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mario R KorteUNKNOWN investigators of the Dutch Multicentre EPS Study
Nov 5, 2011·Journal of the American Society of Nephrology : JASN·Humberto DellêIrene L Noronha
Jan 7, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Paolo PersichettiSergio Morini
Dec 19, 2012·European Journal of Internal Medicine·E F H van BommelT R Hendriksz
Apr 20, 2013·Clinical Rheumatology·Sascha PaetzoldMarianne Brodmann
Jun 2, 2012·Hand : Official Journal of the American Association for Hand Surgery·Josef G HadeedHoward Levinson
Apr 14, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Seyed Reza MousaviShahin Behjoo
Mar 3, 2007·International Urology and Nephrology·Anup KumarRajeev Kumar
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·N AyoubC Frances
Jun 20, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Soo Hyung RyuDong Jin Suh
Jul 22, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·John C Dallon, H Paul Ehrlich
Mar 9, 2006·Skinmed·Alon ScopeMicahel Ehrenfeld
Jun 9, 2016·Journal of Cell Communication and Signaling·Massimiliano TripoliFrancesco Moschella
Aug 13, 2008·The Journal of Hand Surgery, European Volume·A Y ZhangJ Chang
Nov 27, 2007·Current Problems in Surgery·Michael G FranzMartin C Robson
Dec 28, 2016·Plastic and Reconstructive Surgery·Keith A DenklerScott L Hansen
Sep 18, 2013·Foot & Ankle International·Nils T VeithHenning Madry
Feb 28, 2009·The Annals of Otology, Rhinology, and Laryngology·Douglas R JohnstonMarc R Rosen
Oct 3, 2015·Archives of Plastic Surgery·Hannah HeadonKefah Mokbel
Jan 30, 2004·Microsurgery·Senol YildizOzcan Pehlivan
Oct 9, 2015·Prague Medical Report·Miroslav PrůchaPetr Štádler
Feb 3, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying LiuLin Yang
Aug 19, 2007·Plastic and Reconstructive Surgery·Robert B ShawJames Chang
Jan 9, 2013·Biotechnology and Bioengineering·Alexander GolbergMartin L Yarmush
Sep 28, 2017·Archives of Plastic Surgery·Shaban MehrvarzHamid Reza Rasouli
Dec 13, 2018·EMBO Reports·Ernesto CortesArmando E Del Río Hernández
Jul 1, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Edward ChoH Mike Kim
May 11, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Tomoya NishinoShigeru Kohno
Jan 30, 2020·Cancers·Alistair RiceArmando E Del Río Hernández
Feb 26, 2016·Plastic and Reconstructive Surgery·Francesco SegretoPaolo Persichetti
Jan 1, 2016·Expert Opinion on Orphan Drugs·Janelle M Spinazzola, Louis M Kunkel
May 4, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M ForsmanJ Ryhänen
Sep 22, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·G NitzscheM Kendler
Apr 6, 2018·Foot & Ankle International·Melissa EspertJudith F Baumhauer
Jan 22, 2013·The American Journal of Pathology·Olivier M DorchiesUrs T Ruegg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.