PMID: 9649919Jul 3, 1998Paper

Tamoxifen-induced light and electron microscopic changes in the rat testicular morphology and serum hormonal profile of reproductive hormones

Contraception
K GopalkrishnanH S Juneja

Abstract

The effects of oral administration of tamoxifen at doses of 40 and 200 micrograms/kg/day on testicular histology, testicular ultrastructure and serum hormonal profile were studied. The drug was administered to adult male rats over a period of 90 days and the effect was assessed at 10-day intervals. The morphometry, microscopic structures of the testis, including ultrastructure and daily sperm production rate, were evaluated. The hormone profiles of luteinizing hormone (LH), follice-stimulating hormone (FSH), testosterone, and estradiol were studied. The testes from treated animals showed disorganization of tubular elements with increased intercellular space. At day 50, the changes were extensive including presence of phagosomes. Morphometric studies showed a reduction in the spermatid and spermatozoan population (69.3%) with no changes in tubular diameter. The mean Leydig cell area was significantly lowered at day 50, at both doses. The daily sperm production rate was reduced as compared with controls. An array of degenerative changes were revealed by ultrastructural studies. The changes were extensive at day 50 at both doses. The characteristic features were lost in most of the cells with phagolysosomes becoming abundant. The ...Continue Reading

References

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Nov 1, 1993·Journal of Reproduction and Fertility·M K Gill-SharmaH S Juneja

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Citations

Apr 9, 2001·Contraception·M K Gill-SharmaH S Juneja
Jun 19, 2001·Molecular and Cellular Endocrinology·N BalasinorH S Juneja
May 9, 2002·Molecular and Cellular Endocrinology·Nafisa BalasinorH S Juneja
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serge Carreau, Rex A Hess
Jul 15, 2006·Journal of Endocrinological Investigation·N BalasinorH S Juneja
Jul 30, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gregg D CapponMark E Hurtt
Oct 2, 2004·Toxicology·H P GelbkeA Poole
May 31, 2011·Experimental Parasitology·Maha M EissaShefaa M F El Sawy

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