Tamoxifen treatment for intracerebral hemorrhage

Acta Neurochirurgica. Supplement
Qing XieYa Hua

Abstract

Tamoxifen is a selective estrogen receptor modulator. In this study we investigated whether or not tamoxifen reduces intracerebral hemorrhage (ICH)-induced brain injury in rats. In all experiments, adult male Sprague-Dawley rats received an injection of 100 μL autologous whole blood into the right basal ganglia. In the first set of experiments, rats were treated with tamoxifen (2.5 mg/kg or 5 mg/kg, i.p.) or vehicle 2 and 24 h after ICH and were killed at day 3 for brain edema measurement. In the second set of experiments, rats were treated with tamoxifen (5 mg/kg) or vehicle and magnetic resonance imaging (MRI), and behavior tests were performed at days 1, 7, 14 and 28. Rats were killed at day 28 for brain histology. We found that tamoxifen at 5 but not at 2.5 mg/kg reduced perihematomal brain edema at day 3 (p<0.05). Brain histology showed that tamoxifen reduced caudate atrophy at day 28 (p<0.01). Tamoxifen also improved functional outcome (p<0.05). MRI demonstrated a tendency to smaller T2* lesions in tamoxifen-treated rats. However, two out of five rats treated with tamoxifen developed hydrocephalus. These results suggest that tamoxifen has neuroprotective effects in ICH, but the cause of hydrocephalus development following...Continue Reading

Citations

Nov 9, 2016·Frontiers in Neurology·Jian Guan, Gregory W J Hawryluk
May 31, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hong-Yu Wei, Xiao Ma
Aug 25, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew A KirkmanAdrian R Parry-Jones
Apr 7, 2016·International Journal of Molecular Sciences·Brandon P Lucke-WoldJ Marc Simard

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