PMID: 2497052Feb 1, 1989Paper

Tandem genes encoding sigma-factors for consecutive steps of development in Bacillus subtilis

Genes & Development
C Karmazyn-CampelliP Stragier

Abstract

During sporulation, Bacillus subtilis undergoes successive morphological changes that can be arrested at various stages by mutations in many genes. One of these, spoIIGB, encodes a transcriptional factor, sigma E, which is necessary to proceed beyond stage II and to differentiate the cell in two compartments, the forespore and the mother cell. Mutations were introduced in an open reading frame located immediately downstream of spoIIGB. They block sporulation at stage III and define a new gene, spoIIIG, encoding a 260-amino-acid polypeptide highly similar to bacterial sigma-factors. A promoter was identified in the spoIIGB-spoIIIG interval by transcriptional fusion to lacZ. It is turned on 1 hr after the start of sigma E synthesis and is specifically activated in the forespore. The tandemly arranged spoIIGB and spoIIIG genes appear to encode homologous proteins that modulate transcription in a sequential fashion during sporulation.

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Citations

Feb 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J W Gober
Aug 1, 1993·Journal of Neuroscience Research·H Z ShengP G Nelson
Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
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