Tandem gold/silver-catalyzed cycloaddition/hydroarylation of 7-aryl-1,6-enynes to form 6,6-diarylbicyclo[3.2.0]heptanes

Chemistry : a European Journal
Bradley D RobertsonRoss A Widenhoefer

Abstract

Mixtures of [{PCy2(o-biphenyl)}AuCl] and AgSbF6 catalyze the tandem cycloaddition/hydroarylation of 7-aryl-1,6-enynes with electron-rich arenes to form 6,6-diarylbicyclo[3.2.0]heptanes in good yield under mild conditions. Experimental observations point to a mechanism involving gold-catalyzed cycloaddition followed by silver-catalyzed hydroarylation of a bicyclo[3.2.0]hept-1(7)-ene intermediate.

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Citations

Mar 10, 2016·Journal of the American Chemical Society·Seyedmorteza HosseyniXiaodong Shi
Apr 9, 2016·Journal of the American Chemical Society·Dong DingXuefeng Jiang
May 28, 2016·Chemical Communications : Chem Comm·Sravan K ThummanapelliXiaodong Shi
Oct 21, 2017·Chemical Society Reviews·Mélanie M LorionLutz Ackermann
Nov 3, 2020·Chemical Reviews·Mauro MatoAntonio M Echavarren

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