Tandem Nazarov cyclization-michael addition sequence catalyzed by an Ir(III) complex

Journal of the American Chemical Society
Mesfin JankaRichard Eisenberg

Abstract

The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.

Citations

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