Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo

The British Journal of Dermatology
I Angelova-FischerSanja Kezic

Abstract

The barrier perturbation pattern and molecular markers of inflammation upon tandem repeated irritation in chronologically aged skin have not been previously studied. We aimed to investigate the barrier impairment kinetic and in vivo cytokine profile following sequential irritation with sodium lauryl sulfate (SLS) and undiluted toluene (Tol) in aged compared with young skin. Four fields on the volar forearm of healthy aged and young volunteers (median age, respectively, 63.9 and 32.6 years) were sequentially exposed to 0.5% SLS and undiluted toluene in a controlled tandem repeated irritation test; an adjacent nontreated field served as control. The permeability barrier function was monitored by repeated measurements of transepidermal water loss (TEWL), capacitance and erythema every 24 h up to 96 h. The stratum corneum cytokines were harvested by sequential tape stripping and quantified by multiplex bead array and enzyme-linked immunosorbent assay. Compared with young skin, aged skin was characterized by delayed and/or less pronounced alterations in the visual irritation score, TEWL, chromametry a*-value and capacitance, assessed by the respective Δ-values for each parameter and monitoring time point. In both groups, exposure to...Continue Reading

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Citations

Nov 2, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·D FalconeP E J van Erp
Jun 12, 2018·Cutaneous and Ocular Toxicology·Rasika Reddy, Howard Maibach
Oct 25, 2016·Dermatitis : Contact, Atopic, Occupational, Drug·Taylor BraunbergerCory A Dunnick
Feb 9, 2018·The Journal of Allergy and Clinical Immunology·Hansjörg BaurechtStephan Weidinger
May 3, 2021·Clinical Physiology and Functional Imaging·Hemalatha JayabalDan L Bader

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