Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy

American Journal of Nephrology
Guisen LiHaiyan Wang

Abstract

MUC20, an upregulated novel gene in the renal tissues of patients with IgA nephropathy (IgAN), was recently identified. The variable number of tandem repeats (VNTR) polymorphism of the MUC20 gene was detected in several cell lines. In the present study, we investigated a possible association of MUC20 VNTR polymorphism with the clinical manifestations and progression in patients with IgAN. A total of 1,147 Chinese subjects, including 657 patients with IgAN and 490 geographically matched healthy controls, were involved in this investigation. One hundred and thirty-seven patients had been followed up for 60.6 +/- 22.4 months. MUC20 VNTR polymorphism was genotyped by polymerase chain reaction amplification and confirmed by sequencing. The alleles were divided into two groups according to the repeat times of MUC20 VNTR, i.e. small alleles (VNTR repeat times < or = 3) and large alleles (VNTR repeat times >3), and the genotypes of subjects were classified into SS, SL and LL groups. The frequencies of the alleles and genotypes of MUC20 VNTR polymorphisms did not differ between patients with IgAN and healthy controls. Additionally, there was no significant difference in the clinical features. Furthermore, IgAN patients with SL/LL genoty...Continue Reading

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Citations

Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Hsin-Hui YuBor-Luen Chiang
Nov 6, 2007·Genome Research·Matthieu LegendreKevin J Verstrepen
Sep 25, 2007·American Journal of Nephrology·Yuansheng Xie, Xiangmei Chen
Feb 14, 2009·Oral and Maxillofacial Surgery·Hesna Muzeyyen AstarciHuseyin Ustun

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