Tandem termination signals: myth or reality?

FEBS Letters
L L MajorWarren Tate

Abstract

In two Escherichia coli genomes, laboratory strain K-12 and pathological strain O157:H7, tandem termination codons as a group are slightly over-represented as termination signals. Individually however, they span the range of representations, over, as expected, or under, in one or both of the strains. In vivo, tandem termination codons do not make more efficient signals. The second codon can act as a backstop where readthrough of the first has occurred, but not at the expected efficiency. UGAUGA remains an enigma, highly over-represented, but with the second UGA a relatively inefficient back up stop codon.

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Citations

Mar 19, 2009·Journal of Molecular Evolution·Marie Adachi, Andre R O Cavalcanti
Nov 18, 2010·Journal of Molecular Evolution·Anna A VakhrushevaGeorgii A Bazykin
Dec 9, 2003·Journal of Molecular Biology·Lukas RajkowitschJohn E G McCarthy
Aug 2, 2011·BMC Evolutionary Biology·Louise J JohnsonSteven C Le Comber
Apr 19, 2005·Genome Biology·Han LiangLaura F Landweber
Apr 7, 2005·RNA·Iwona K WowerJacek Wower
May 5, 2011·Gene·Alex V KochetovIgor B Rogozin
Sep 14, 2014·The Journal of Biological Chemistry·Gürkan KorkmazSuparna Sanyal
Feb 20, 2019·Nature Communications·John D LueckChristopher A Ahern
Aug 17, 2020·Molecular Biology and Evolution·Alexander T Ho, Laurence D Hurst
Nov 10, 2021·Molecular Biology and Evolution·Alexander T Ho, Laurence D Hurst

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