Tandemly repeated DNA: why should anyone care?

Mutation Research
John A L Armour

Abstract

Recent excitement over SNPs has tended to obscure the real advantages of studying tandemly repeated loci. In this commentary, I make the case for studying tandem repeats, concentrating on two major arguments. Firstly, tandemly repeated loci are unrivalled as a source of detailed mechanistic information in studies of variation and mutation, and are highly informative reporters of genomic instability in studies of induced mutation. Secondly, changes at many tandem repeats have important functional consequences, and in addition to examples of "strong" single-gene effects such as those at the triplet repeat disease loci, there may well be a much larger number of loci at which subtler functional effects remain to be discovered.

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Citations

Dec 30, 2008·Human Genetics·Christopher M Somers, David N Cooper
May 13, 2010·BMC Evolutionary Biology·Damien ChevanneMathieu Paoletti
Oct 8, 2009·BMC Research Notes·Isabelle ColsonDieter Ebert
Oct 31, 2006·Radiation and Environmental Biophysics·Wael Abdel MegidJeff W Bacher
Aug 5, 2008·Gene·Gary W Moy, Victor D Vacquier
Oct 22, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aurora Ruiz-Herrera, Terence J Robinson
Aug 27, 2010·Environmental and Molecular Mutagenesis·Timothy M Singer, Carole L Yauk
Nov 26, 2013·Environmental and Molecular Mutagenesis·Lifang HouAndrea A Baccarelli
Sep 14, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Lingling ZhangZhenmin Bao
May 21, 2014·Molecular Biology Reports·Qi WuChuan Tang Wang
Jun 5, 2007·Cancer Research·Carole L YaukMartin R Stämpfli
Aug 24, 2018··Travis WheelerDaniel Olson

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