PMID: 9436786Jan 22, 1998Paper

Tangential migration of ameboid microglia in the developing quail retina: mechanism of migration and migratory behavior

Glia
J L Marín-TevaJ Navascués

Abstract

Long distance migration of microglial precursors within the central nervous system is essential for microglial colonization of the nervous parenchyma. We studied morphological features of ameboid microglial cells migrating tangentially in the developing quail retina to shed light on the mechanism of migration and migratory behavior of microglial precursors. Many microglial precursors remained attached on retinal sheets containing the inner limiting membrane covered by a carpet of Müller cell endfeet. This demonstrates that most ameboid microglial cells migrate tangentially on Müller cell endfeet. Many of these cells showed a central-to-peripheral polarized morphology, with extensive lamellipodia spreading through grooves flanked by Müller cell radial processes, to which they were frequently anchored. Low protuberances from the vitreal face of microglial precursors were firmly attached to the subjacent basal lamina, which was accessible through gaps in the carpet of Müller cell endfeet. These results suggest a mechanism of migration involving polarized extension of lamellipodia at the leading edge of the cell, strong cell-to-substrate attachment, translocation of the cell body forward, and retraction of the rear of the cell. Oth...Continue Reading

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Citations

Oct 7, 1998·Progress in Neurobiology·M A Cuadros, J Navascués
Mar 12, 2011·Developmental Neurobiology·Maria-Carmen CarrascoJosé L Marín-Teva
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna L XavierMaiken Nedergaard
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Nov 21, 2007·The Journal of Comparative Neurology·Ana M SantosMiguel A Cuadros
Sep 22, 2005·The Journal of Comparative Neurology·Ana M Sánchez-LópezJulio Navascués
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Jul 5, 2001·Journal of Neuroscience Research·J H SeoS S Cho
Apr 13, 2000·Brain Research. Brain Research Reviews·J Mey, S Thanos
Sep 20, 2021·Anatomical Science International·Yuki Hattori

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