Abstract
Epilepsy is complex neural disarray categorized by recurring seizures. Despite recent advances in pharmacotherapies for epilepsy, its treatment remains a challenge due to the contrary effects of the drugs. As a result, the identification of novel anti-epileptic drugs (AEDs) with neuroprotective properties and few side effects is of great value. Thus, the present study assessed the treatment effects of tangeretin using a rat model of pilocarpine-induced epilepsy. Separate groups of male Wistar rats received oral administrations of tangeretin at 50, 100, or 200mg/kg for 10 days and then, on the 10th day, they received an intraperitoneal injection of pilocarpine (30mg/kg). Subsequently, neuronal degeneration and apoptosis were assessed using Nissl staining and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay procedures. Additionally, the expressions of phosphatidylinositol-3-kinase (PI3K/Akt) pathway proteins, cleaved caspase-3, Bad, Bcl-2, Bcl-xL, and Bax were determined using Western blot analyses. Tangeretin reduced the seizure scores and latency to first seizure of the rats and effectively activated the pilocarpine-induced suppression of PI3K/Akt signaling. Additionally, tangeretin effe...Continue Reading
Citations
Dec 30, 2017·Pharmaceutics·Mai Gamal Elhennawy, Hai-Shu Lin
Sep 28, 2018·Journal of Cellular Biochemistry·Chunfang WuYouran Zhang
Jan 24, 2019·Bioscience Reports·Enjun ZuoFengyuan Piao
Jan 24, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Huai TaoYong Liu
Dec 12, 2018·Molecular Medicine Reports·Qiang LiuHaibin Li
Oct 3, 2018·International Journal of Molecular Medicine·Ping DongBo Yang
Apr 25, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Milad AshrafizadehElham Ghasemipour Afshar
Jan 27, 2019·Neuroscience Bulletin·Ai-Hua LiuYu-Ping Wang
Mar 19, 2020·Frontiers in Pharmacology·Shenhai LiuTao Sun
May 7, 2020·Frontiers in Pharmacology·Jing LuJian Wang
Mar 17, 2019·Neurochemical Research·Jinli WangHongyang Zhao
Mar 1, 2019·International Journal of Molecular Sciences·Jen-Jie LinYu-Jen Wu
Jan 1, 2019·Cell Cycle·Hongmei DaiZhiheng Chen
Dec 18, 2020·Cell Transplantation·Jian XuJian Gao
Nov 29, 2020·Brain Research Bulletin·Hao WuHua Zhang
Jan 8, 2021·Nutrients·Kentaro Matsuzaki, Yasushi Ohizumi
Mar 28, 2021·The Journal of Pharmacy and Pharmacology·Sarah S El-SayedAyman E El-Sahar
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Adam HermawanMuthi Ikawati
Jun 7, 2018·Journal of Agricultural and Food Chemistry·Fuqiang LiangXiaoyun Xu
Aug 29, 2019·Journal of Agricultural and Food Chemistry·Ji-Yue ShaWei Li
Aug 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sajad FakhriJianbo Xiao